Molecular Neuroendocrinology of Food Intake (NMPA), UMR 9197, University of Paris-Saclay, Orsay, France; NMPA, Dept. Development, Evolution and Cell Signaling, Paris-Saclay Institute of Neurosciences (NeuroPSI) CNRS UMR 9197, Orsay, France.
Molecular Neuroendocrinology of Food Intake (NMPA), UMR 9197, University of Paris-Saclay, Orsay, France; NMPA, Dept. Development, Evolution and Cell Signaling, Paris-Saclay Institute of Neurosciences (NeuroPSI) CNRS UMR 9197, Orsay, France.
Mol Cell Endocrinol. 2021 Aug 1;533:111341. doi: 10.1016/j.mce.2021.111341. Epub 2021 May 31.
Resistin has been firstly discovered in mice and was identified as an adipose tissue-secreted hormone or adipokine linking obesity and insulin resistance. In humans, resistin has been characterized as a hormone expressed and secreted by Immune cells especially by macrophages, and was linked to many inflammatory responses including inflammation of adipose tissue due to macrophages' infiltration. Human and mouse resistin display sequence and structural similarities and also dissimilarities that could explain their different expression pattern. In mice, strong pieces of evidence clearly associated high resistin plasma levels to obesity and insulin resistance suggesting that resistin could play an important role in the onset and progression of obesity and insulin resistance via resistin-induced inflammation. In humans, the link between resistin and obesity/insulin resistance is still a matter of debate and needs more epidemiological studies. Also, resistin has been linked to other chronic diseases such as cardiovascular diseases and cancers where resistin has been proposed in many studies as a biological marker.
抵抗素最初在小鼠中被发现，被鉴定为一种脂肪组织分泌的激素或脂肪因子，将肥胖与胰岛素抵抗联系起来。在人类中，抵抗素被描述为免疫细胞特别是巨噬细胞表达和分泌的激素，与许多炎症反应有关，包括由于巨噬细胞浸润导致的脂肪组织炎症。人和鼠抵抗素显示出序列和结构的相似性和差异性，这可以解释它们不同的表达模式。在小鼠中，强有力的证据明确将高抵抗素血浆水平与肥胖和胰岛素抵抗联系起来，表明抵抗素可能通过抵抗素诱导的炎症在肥胖和胰岛素抵抗的发生和进展中发挥重要作用。在人类中，抵抗素与肥胖/胰岛素抵抗之间的联系仍然存在争议，需要更多的流行病学研究。此外，抵抗素还与其他慢性疾病如心血管疾病和癌症有关，在许多研究中，抵抗素被提出作为一种生物标志物。
