Elias D, Lasser P H, Bognel C, Nadal J M, Rahal K, Pineda R, Rougier P
Service de Chirurgie Digestive Carcinologique, Institut Gustave-Roussy, Villejuif.
Gastroenterol Clin Biol. 1988 Oct;12(10):729-35.
One hundred and twelve curatively resected gastric adenocarcinomas were studied retrospectively to appreciate the survival factors. Twenty different criteria (clinic, histologic and therapeutic parameters) were assessed using univariate and then multivariate analysis (semi parametric regression (COX's) model). Only three criteria were very important according to the multivariate analysis: 1) invasion of neighboring organs (p less than 0.006) with a relative risk score (RRS) of 4.26; 2) intravascular or intralymphatic tumor embols outside the tumor (p less than 0.004; RRS = 2.11); 3) invaded distal nodes (located at the origin of the vessels (p less than 0.04; RRS = 1.88). A prognosis index was described according to these results. A repartition of the patients in three prognostic groups according to these 3 criteria was proposed. Future, trials should consider these three different prognostic groups.
对112例接受根治性切除的胃腺癌患者进行回顾性研究，以了解生存因素。使用单因素分析，然后进行多因素分析（半参数回归（COX）模型）评估20个不同标准（临床、组织学和治疗参数）。根据多因素分析，只有三个标准非常重要：1）侵犯邻近器官（p<0.006），相对风险评分（RRS）为4.26；2）肿瘤外血管内或淋巴管内肿瘤栓塞（p<0.004；RRS=2.11）；3）侵犯远处淋巴结（位于血管起源处，p<0.04；RRS=1.88）。根据这些结果描述了一个预后指数。根据这三个标准将患者分为三个预后组。未来的试验应考虑这三个不同的预后组。
