Shukla Abhilasha, Singh Narendra Nath, Adsul Sangeeta, Kumar Sulabh, Shukla Deepika, Sood Anubhuti
Department of Oral Pathology and Microbiology, Babu Banarasi Das College of Dental Sciences, Lucknow, Uttar Pradesh, India.
Department of Oral Pathology and Microbiology, Kothiwal Dental College & Research Centre, Moradabad, Uttar Pradesh, India.
J Oral Maxillofac Pathol. 2018 Sep-Dec;22(3):442. doi: 10.4103/jomfp.JOMFP_261_17.
Early detection of oral cancer is of paramount importance in determining the prognosis of oral cancer. Literature suggests that several diagnostic modalities have been proposed to aid a clinician in early detection of oral cancer without much conclusive evidence.
The present study aims to compare toluidine blue and chemiluminescence screening methods in early detection of carcinoma in North Indian population and also to evaluate these methods with histopathological diagnosis.
In this prospective study, 42 patients with clinically visible premalignant lesions were included. Demographic data were collected, and suspicious lesions were examined by chemiluminescence light (Vizilite) and followed by local application of toluidine blue (Mashberg's recommendation). Findings were recorded for each lesion under standard incandescent light as positive or negative. Biopsy and histopathological analysis of the tissues were performed.
Sensitivity, specificity and positive and negative predictive values for the chemiluminescence technique and toluidine blue were calculated for diagnostic tests.
In the present study, toluidine blue test was found to be moderately sensitive (63.33%) whereas chemiluminescence test (Vizilite) was found to be highly sensitive (90%); however, the test has limited specificity (50%). Thus, the study concluded that both toluidine blue and Vizilite can be used as an adjunct to simple, conventional visual examination and in screening procedure for oral potentially malignant disorders.
口腔癌的早期检测对于确定口腔癌的预后至关重要。文献表明，已经提出了几种诊断方法来帮助临床医生早期检测口腔癌，但没有太多确凿的证据。
本研究旨在比较甲苯胺蓝和化学发光筛查方法在印度北部人群口腔癌早期检测中的效果，并通过组织病理学诊断评估这些方法。
在这项前瞻性研究中，纳入了42例临床上可见的癌前病变患者。收集人口统计学数据，对可疑病变进行化学发光检查（Vizilite），然后局部应用甲苯胺蓝（Mashberg推荐方法）。在标准白炽灯下记录每个病变的结果为阳性或阴性。对组织进行活检和组织病理学分析。
计算化学发光技术和甲苯胺蓝诊断测试的敏感性、特异性以及阳性和阴性预测值。
在本研究中，发现甲苯胺蓝测试具有中等敏感性（63.33%），而化学发光测试（Vizilite）具有高度敏感性（90%）；然而，该测试的特异性有限（50%）。因此，该研究得出结论，甲苯胺蓝和Vizilite均可作为简单常规视觉检查的辅助手段，用于口腔潜在恶性疾病的筛查程序。
