Qin Xiaoming, Qin Lei, Luo Jiachen, Liu Baoxin, Zhao Jinlong, Li Hongqiang, Wei Yidong
Department of Cardiology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, Shanghai 200072, P.R. China.
Department of Cardiology, Kaifeng Central Hospital, Kaifeng, Henan 475000, P.R. China.
Exp Ther Med. 2019 Jan;17(1):418-422. doi: 10.3892/etm.2018.6944. Epub 2018 Nov 8.
The aim of the study was to investigate the correlation between levels of 25-hydroxyvitamin D3, vitamin B12 and C and endothelial function of patients with coronary heart disease (CHD). Forty patients with CHD diagnosed in Shanghai Tenth People's Hospital from May 2016 to April 2017 were selected as the observation group. A total of 45 healthy individuals were selected as the control group. The participants included 54 males and 31 females. General information was collected. Peripheral serum biochemical indicators, levels of 25-hydroxyvitamin D3, vitamin B12 and C, homocysteine (Hcy), nitric oxide (NO) and endothelial NOS (eNOS) were measured. Arterial lesions detected by coronary angiography were recorded and indexes of observation and control group were compared for the correlation analysis. A proportion of hypertensive patients and their body mass index (BMI) were significantly higher in the observation than in the control group (P<0.05). Levels of 25-hydroxyvitamin D3, vitamin B12 and C in peripheral blood of observation were significantly lower than those of the control group (P<0.05). Compared with the control group, incidence of single-branch lesion and non-lesion rate were significantly lower, but incidence of double- and triple-branch lesions were significantly higher in observation than in control group (P<0.05). In addition, the level of Hcy in the observation group was higher than that in the control group, but levels of NO and eNOS in observation were significantly lower than those in control group (P<0.05. The correlation analysis revealed that 25-hydroxyvitamin D3 (r=0.792, P<0.01), vitamin B12 (r=0.635, P<0.01) and vitamin C (r=0.703, P<0.01) were negatively correlated with serum NO level. Thus, hypertension, BMI, 25-hydroxyvitamin D3, vitamin B12 and C have independent predictive value for coronary endothelial dysfunction (P<0.05). In conclusion, serum levels of 25-hydroxyvitamin D3, vitamin B12 and C are closely related to vascular endothelial dysfunction in patients with CHD and affect the severity of vascular endothelial dysfunction in patients with CHD.
本研究旨在探讨冠心病（CHD）患者25-羟基维生素D3、维生素B12和维生素C水平与内皮功能之间的相关性。选取2016年5月至2017年4月在上海第十人民医院确诊的40例冠心病患者作为观察组。选取45例健康个体作为对照组。参与者包括54名男性和31名女性。收集一般资料。检测外周血清生化指标、25-羟基维生素D3、维生素B12和维生素C水平、同型半胱氨酸（Hcy）、一氧化氮（NO）和内皮型一氧化氮合酶（eNOS）。记录冠状动脉造影检测到的动脉病变，并比较观察组和对照组的指标进行相关性分析。观察组高血压患者比例及其体重指数（BMI）显著高于对照组（P<0.05）。观察组外周血25-羟基维生素D3、维生素B12和维生素C水平显著低于对照组（P<0.05）。与对照组相比，观察组单支病变发生率和无病变率显著较低，但双支和三支病变发生率显著较高（P<0.05）。此外，观察组Hcy水平高于对照组，但观察组NO和eNOS水平显著低于对照组（P<0.05）。相关性分析显示，25-羟基维生素D3（r=0.792，P<0.01）、维生素B-12（r=0.635，P<0.01）和维生素C（r=0.703，P<0.01）与血清NO水平呈负相关。因此，高血压、BMI、25-羟基维生素D3、维生素B12和维生素C对冠状动脉内皮功能障碍具有独立预测价值（P<0.05）。总之，冠心病患者血清25-羟基维生素D3、维生素B12和维生素C水平与血管内皮功能障碍密切相关，并影响冠心病患者血管内皮功能障碍的严重程度。
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