Wu Peng, Ma Juan, Yang Shaobin, Wu Hailiang, Ma Xueping, Chen Dapeng, Jia Shaobin, Yan Ning
First Clinical College, Ningxia Medical University, Yinchuan, China.
Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China.
Front Nutr. 2024 May 3;11:1379096. doi: 10.3389/fnut.2024.1379096. eCollection 2024.
The yearly escalation in hypertension prevalence signifies a noteworthy public health challenge. Adhering to a nutritious diet is crucial for enhancing the quality of life among individuals managing hypertension. However, the relationship between vitamin C and hypertension, as well as homocysteine, remains unclear.
The primary aim of this investigation was to scrutinize the potential mediating role of Vitamin C in the association between homocysteine levels and blood pressure, utilizing data extracted from the National Health and Nutrition Examination Survey (NHANES) database.
A total of 7,327 participants from the NHANES 2003-2006 were enrolled in this cross-sectional survey. The main information was obtained using homocysteine, Vitamin C, systolic blood pressure (SBP) and diastolic blood pressure (DBP). Correlation analysis was used to assess the correlation between homocysteine, SBP, DBP and vitamin C. Linear regression analysis was utilized to determine the β value (β) along with its 95% confidence intervals (CIs). Mediation analysis was performed to investigate whether the relationship between homocysteine and blood pressure was mediated by Vitamin C, and to quantify the extent to which Vitamin C contributed to this association.
The results manifested that the homocysteine was positively associated with SBP ( = 0.24, < 0.001) and DBP ( = 0.03, < 0.05), while negatively correlated with Vitamin C ( = -0.008, < 0.001). Vitamin C was found to be negatively associated with SBP ( = -0.03, < 0.05) and DBP ( = 0.11, < 0.001). Mediation effect analysis revealed that a partial mediation (indirect effect: 0.0247[0.0108-0.0455], < 0.001) role accounting for 11.5% of total effect, among homocysteine and SBP. However, the mediating effect of Vitamin C between homocysteine and DBP was not statistically significant.
Hypertension patients should pay attention to homocysteine and Vitamin C level. What is more, hypertension patients ought to formulate interventions for Vitamin C supplementation as well as homocysteine reduce strategies to lower blood pressure.
高血压患病率逐年上升，这是一个值得关注的公共卫生挑战。坚持营养饮食对于提高高血压患者的生活质量至关重要。然而，维生素C与高血压以及同型半胱氨酸之间的关系仍不明确。
本研究的主要目的是利用从美国国家健康与营养检查调查（NHANES）数据库中提取的数据，探讨维生素C在同型半胱氨酸水平与血压之间的关联中可能的中介作用。
本横断面调查共纳入了2003 - 2006年NHANES的7327名参与者。主要信息通过同型半胱氨酸、维生素C、收缩压（SBP）和舒张压（DBP）获得。采用相关性分析评估同型半胱氨酸、SBP、DBP与维生素C之间的相关性。利用线性回归分析确定β值（β）及其95%置信区间（CIs）。进行中介分析以研究同型半胱氨酸与血压之间的关系是否由维生素C介导，并量化维生素C对这种关联的贡献程度。
结果表明，同型半胱氨酸与SBP呈正相关（ = 0.24， < 0.001），与DBP呈正相关（ = 0.03， < 0.05），而与维生素C呈负相关（ = -0.008， < 0.001）。维生素C与SBP呈负相关（ = -0.03， < 0.05），与DBP呈负相关（ = 0.11， < 0.001）。中介效应分析显示，在同型半胱氨酸和SBP之间存在部分中介作用（间接效应：0.0247[0.0108 - 0.0455]， < 0.001），占总效应的11.5%。然而，维生素C在同型半胱氨酸和DBP之间的中介作用无统计学意义。
高血压患者应关注同型半胱氨酸和维生素C水平。此外，高血压患者应制定补充维生素C的干预措施以及降低同型半胱氨酸的策略来降低血压。
