Spreafico F
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Fundam Clin Pharmacol. 1988;2(4):353-67. doi: 10.1111/j.1472-8206.1988.tb00646.x.
After the definition of immunotoxicology and of the main current domains of this recently recognized, multifaceted discipline, this article examines the health significance of xenobiotically induced immune abnormalities and considers the possible mechanisms through which damage to the immune system can occur. In the second part of this review, the current status of knowledge and the problems still open with regard to preclinical testing for nonallergic immunotoxicities are examined, and current views on the general strategy for such testing discussed.
在对免疫毒理学以及这一最近才被认识到的多方面学科的主要当前领域进行定义之后，本文探讨了异源生物诱导的免疫异常对健康的意义，并考虑了免疫系统可能受到损害的机制。在本综述的第二部分，研究了关于非过敏性免疫毒性临床前测试的当前知识状况和仍未解决的问题，并讨论了关于此类测试总体策略的当前观点。
