Shukla Hitesh, Mason Jessica Louise, Sabyah Abdullah
Rightangled Ltd, The Relay Building, 114 Whitechapel High St, London E1 7PT, UK.
Future Sci OA. 2018 Oct 26;5(1):FSO350. doi: 10.4155/fsoa-2018-0031. eCollection 2019 Jan.
The development of cardiovascular diseases (CVDs) is due to a complex interaction between the genome and the environment. Understanding how genetic differences in individuals contribute to their susceptibility to CVDs can help guide practitioners to give the best advice to achieve a favorable outcome for the patient. As genome technologies evolve, genotyping of individuals could be available to all patients using a simple saliva test. Large-scale genome-wide association studies and meta analyses have provided powerful insights into polymorphisms that may be predictive of disease and an individual's response to certain nutrients, but moving forward it is imperative that these insights can be applied in the medical setting to reduce the incidence and mortality of CVDs.
心血管疾病（CVDs）的发生是基因组与环境之间复杂相互作用的结果。了解个体的基因差异如何导致其对心血管疾病的易感性，有助于指导医生提供最佳建议，以实现对患者有利的治疗结果。随着基因组技术的发展，所有患者都可以通过简单的唾液检测进行基因分型。大规模全基因组关联研究和荟萃分析为可能预测疾病以及个体对某些营养素反应的多态性提供了有力的见解，但未来必须将这些见解应用于医疗环境，以降低心血管疾病的发病率和死亡率。
