Jóźwiak Jacek J, Kasperczyk Sławomir, Tomasik Tomasz, Osadnik Tadeusz, Windak Adam, Studziński Krzysztof, Mastej Mirosław, Catapano Alberico, Ray Kausik K, Mikhailidis Dimitri P, Toth Peter P, Howard George, Lip Gregory Y H, Tomaszewski Maciej, Charchar Fadi J, Sattar Naveed, Williams Bryan, MacDonald Thomas M, Krzemień Paweł, Dobrakowski Michał, Kasperczyk Aleksandra, Nowak Dariusz, Skowron Łukasz, Żak Żaneta, Lewek Joanna, Banach Maciej
Department of Family Medicine and Public Health, Faculty of Medicine, University of Opole, Opole, Poland.
Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Arch Med Sci. 2020 Jun 4;18(3):604-616. doi: 10.5114/aoms.2020.96052. eCollection 2022.
Cardiovascular disease (CVD) is a major cause of morbidity and mortality throughout the world. The LIPIDOGRAM2015 study was performed to estimate the prevalence of risk factors for atherosclerotic diseases as well as cardiovascular and related disorders in the primary care setting in Poland. The LIPIDOGEN2015 sub-study was designed to include a random cohort of patients in order to analyse parameters related to lipid metabolism, oxidative stress, inflammatory responses, autoimmune disorders, and gene variants that confer susceptibility to cardiometabolic and atherosclerotic diseases.
The recruitment was carried out by 438 primary care physicians in Poland. The expected number of patients recruited for the LIPIDOGRAM2015 study was 13,000-14,000 with 13-15% (1700-2000) also participating in the LIPIDOGEN2015 sub-study. Each patient had to complete a questionnaire concerning medical and family history, concomitant diseases, and pharmacotherapy. Anthropometric measurements were performed at the doctor's office. For the LIPIDOGEN2015 sub-study, saliva samples for DNA isolation and blood samples for measurement of glycated haemoglobin, oxidative stress parameters, autoantibody levels, and inflammatory cytokine profile and apolipoprotein profile were collected. Follow-up data will be obtained from the National Health Fund in Poland.
The LIPIDOGRAM2015 and LIPIDOGEN2015 study cohort reflects the prevalence of cardiovascular risk factors and concomitant diseases, markers of oxidative stress, the presence of autoantibodies, inflammatory cytokine profile, and apolipoprotein profile, as well as genetic variants potentially conferring susceptibility to cardiometabolic and atherosclerotic diseases.
This study presents the prevalence of different CV risk factors, with special emphasis on lipid disorders, and it assesses the relationship between inflammation, oxidative stress, and mutations in genes encoding proteins regulating lipid metabolism, as well as genes conferring susceptibility to cardiovascular, cardiometabolic, and related diseases.
心血管疾病（CVD）是全球发病和死亡的主要原因。开展LIPIDOGRAM2015研究旨在评估波兰初级保健机构中动脉粥样硬化疾病以及心血管及相关疾病危险因素的患病率。LIPIDOGEN2015子研究旨在纳入一组随机患者队列，以分析与脂质代谢、氧化应激、炎症反应、自身免疫性疾病以及赋予心脏代谢和动脉粥样硬化疾病易感性的基因变异相关的参数。
招募工作由波兰的438名初级保健医生进行。LIPIDOGRAM2015研究预计招募患者13000 - 14000名，其中13% - 15%（1700 - 2000名）也参与LIPIDOGEN2015子研究。每位患者必须完成一份关于医疗和家族病史、伴随疾病及药物治疗的问卷。人体测量在医生办公室进行。对于LIPIDOGEN2015子研究，采集唾液样本用于DNA分离，采集血液样本用于测量糖化血红蛋白、氧化应激参数、自身抗体水平、炎症细胞因子谱和载脂蛋白谱。随访数据将从波兰国家卫生基金获取。
LIPIDOGRAM2015和LIPIDOGEN2015研究队列反映了心血管危险因素和伴随疾病的患病率、氧化应激标志物、自身抗体的存在、炎症细胞因子谱和载脂蛋白谱，以及可能赋予心脏代谢和动脉粥样硬化疾病易感性的基因变异情况。
本研究呈现了不同心血管危险因素的患病率，特别强调了脂质紊乱情况，并评估了炎症、氧化应激与调节脂质代谢的蛋白质编码基因中的突变以及赋予心血管、心脏代谢和相关疾病易感性的基因之间的关系。
