Zhao Zuo-Yu, Che Ping, Glassman Kimberly, Albertsen Marc
Corteva Agriscience™, Agriculture Division of DowDuPont™, Johnston, IA, USA.
Methods Mol Biol. 2019;1931:197-207. doi: 10.1007/978-1-4939-9039-9_14.
To help alleviate malnutrition in Africa, nutritionally enhanced sorghum was developed through genetic transformation to increase pro-vitamin A (β-carotene) accumulation and stability, to improve iron and zinc bioavailability, and to improve protein digestibility. Through many years of efforts, significant achievements have been made for these goals. We generated nutritionally enhanced sorghum lines with enhanced and stabilized pro-vitamin A that provide 20-90% of the Estimated Average Requirement (EAR) for children under age 3, lines with a 90% reduction in phytate that increase iron and zinc bioavailability and provide 40-80% of the EAR for iron and zinc, and lines that show no reduction in protein digestibility after cooking compared with normal levels. Once these nutritionally enhanced sorghum lines have undergone biosafety examination and have been deregulated, they will be ready for incorporation into sorghum varieties that will benefit Africa and other areas that rely upon sorghum as a staple food.
为帮助缓解非洲的营养不良状况，通过基因转化培育出了营养强化高粱，以增加维生素A原（β-胡萝卜素）的积累和稳定性，提高铁和锌的生物利用率，并改善蛋白质消化率。经过多年努力，在这些目标上取得了显著成就。我们培育出了营养强化高粱品系，其维生素A原得到增强和稳定，可为3岁以下儿童提供估计平均需求量（EAR）的20%-90%；培育出了植酸含量降低90%的品系，可提高铁和锌的生物利用率，并提供铁和锌EAR的40%-80%；还培育出了烹饪后蛋白质消化率与正常水平相比没有降低的品系。一旦这些营养强化高粱品系通过生物安全检查并解除管制，它们将可用于培育高粱品种，造福非洲以及其他依赖高粱作为主食的地区。
