Onukwugha Eberechukwu, Jayasekera Jinani, Gardner James, Malik Sana, Mullins C Daniel, Hussain Arif, Ciezki Jay P, Reddy Chandana A, Seal Brian, Valderrama Adriana, Kwok Young
Eberechukwu Onukwugha, Jinani Jayasekera, James Gardner, C. Daniel Mullins, Arif Hussain, and Young Kwok, University of Maryland; Arif Hussain, Veterans Affairs Medical Center, Baltimore; Sana Malik, University of Maryland, College Park, MD; Jay P. Ciezki and Chandana A. Reddy, Cleveland Clinic Foundation, Cleveland, OH; and Brian Seal and Adriana Valderrama, Bayer HealthCare Pharmaceuticals, Pine Brook, NJ.
JCO Clin Cancer Inform. 2018 Dec;2:1-12. doi: 10.1200/CCI.17.00075.
There is limited information on the use of data visualization tools for health services research applications. We provide a proof-of-concept application that focuses on claims-based measures of palliative radiation therapy. We investigate whether a guided, data-driven investigation contributes information for subsequent statistical analysis and algorithm development.
This retrospective cohort study used linked registry and claims data on men who were diagnosed with stage IV M0 or stage IV M1b prostate cancer between 2005 and 2009, with associated claims from 2005 through 2010, and receiving radiation therapy. Preprocessing of data was accomplished by using EventFlow software to investigate longitudinal patterns in claims for radiation therapy in the 13 months after cancer diagnosis. Guided by results from EventFlow, we developed descriptive statistics to investigate the length of radiation therapy, use of bone metastasis coding, and mortality between M1b and M0 patients.
A total of 1,151 patients met the inclusion criteria. Taking advantage of the novel aggregation capability of EventFlow, we observed differences in the length of radiation therapy and the use of bone metastasis coding between men with (M1b) and without (M0) a diagnosis of bone metastasis. Seventy-nine percent of M1b patients received radiation for a duration ≤ 4 weeks, which suggested palliative radiation (to the bone). Seventy-six percent of M0 patients received radiation for ≥ 6 weeks, which suggested radiation to the prostate. Mortality was higher among those who received a shorter duration of radiation therapy compared with those who received a longer duration of therapy.
Use of EventFlow, followed by statistical analysis of the linked registry and claims data, identified useful components of a claims-based measure of radiation to the bone.
关于将数据可视化工具用于健康服务研究应用的相关信息有限。我们提供了一个概念验证应用,其聚焦于基于索赔的姑息性放射治疗指标。我们调查了一次有指导的数据驱动型调查是否能为后续的统计分析和算法开发提供信息。
这项回顾性队列研究使用了2005年至2009年间被诊断为IV期M0或IV期M1b前列腺癌男性的关联登记和索赔数据,以及2005年至2010年的相关索赔数据,这些男性均接受了放射治疗。数据预处理通过使用EventFlow软件来完成,以研究癌症诊断后13个月内放射治疗索赔的纵向模式。在EventFlow结果的指导下,我们制定了描述性统计方法,以研究放射治疗时长、骨转移编码的使用情况以及M1b和M0患者之间的死亡率。
共有1151名患者符合纳入标准。利用EventFlow新颖的汇总功能,我们观察到有(M1b)和无(M0)骨转移诊断的男性在放射治疗时长和骨转移编码使用方面存在差异。79%的M1b患者接受放射治疗的时长≤4周,这表明是姑息性放射治疗(针对骨骼)。76%的M0患者接受放射治疗的时长≥6周,这表明是针对前列腺的放射治疗。与接受较长时长放射治疗的患者相比,接受较短时长放射治疗的患者死亡率更高。
使用EventFlow,随后对关联登记和索赔数据进行统计分析,确定了基于索赔的骨骼放射治疗指标中的有用组成部分。