Herek Thalita Caroline, Menegazzo Vinícius Ribeiro, Ogaki Mayara Baptistucci, Perini Hugo Felix, Maia Luciana Furlaneto, Furlaneto Marcia Cristina
Departamento de Microbiologia, Universidade Estadual de Londrina, Londrina, PR, Brasil.
Departamento de Ortopedia e Traumatologia, Universidade Estadual de Londrina, Londrina, PR, Brasil.
Rev Soc Bras Med Trop. 2019 Jan 17;52:e20180182. doi: 10.1590/0037-8682-0182-2018.
Administration of total parenteral nutrition (TPN) via catheters increases the risk for candidemia from Candida parapsilosis.
C. parapsilosis sensu stricto blood isolates were evaluated for ability total biomass biofilm formation and morphogenesis in presence of glucose at TPN equivalent concentrations.
Biofilms were increased at high glucose concentrations (25-30%) compared to the control medium. Significant increase in filamentous forms was observed in cultures with 30% glucose.
Biofilm formation by C. parapsilosis sensu stricto in hyperglycidic medium may contribute to its pathogenic potential for fungemia related to TPN catheters.
通过导管给予全胃肠外营养（TPN）会增加近平滑念珠菌引起念珠菌血症的风险。
评估近平滑念珠菌狭义种血液分离株在TPN等效浓度的葡萄糖存在下形成总生物量生物膜的能力和形态发生情况。
与对照培养基相比，高葡萄糖浓度（25 - 30%）下生物膜增加。在含30%葡萄糖的培养物中观察到丝状形式显著增加。
近平滑念珠菌狭义种在高糖培养基中形成生物膜可能有助于其与TPN导管相关的真菌血症的致病潜力。
