a Department of Physiology, School of Medicine , National and Kapodistrian University of Athens , Athens , Greece.
Expert Rev Clin Immunol. 2019 Apr;15(4):417-429. doi: 10.1080/1744666X.2019.1571411. Epub 2019 Feb 8.
Cardiovascular (CV) events, as a result of accelerated atherosclerosis, are an important cause of mortality in patients with Systemic lupus erythematosus (SLE). The etiology of SLE is multifactorial and still unclear; among other potential culprits, excessive B cell activation seems to play a crucial role. Accumulating evidence supports a contributory role of B cells in the pathogenesis of atherosclerosis as well. Areas covered: This article focuses on the contribution of both B cells and autoantibodies in the pathogenesis of atherosclerosis in both general and lupus populations. Review of the published literature on experimental models has also been performed. Expert opinion: Distinct B cell subsets seem to exhibit separate effects on the progression of atherosclerosis, with B2 B cells displaying a mainly atherogenic phenotype, while B1 B cells are mostly viewed as atheroprotective. Selective B2 inhibition by anti-B cell therapies seems a promising therapeutic strategy against atherosclerosis development in the setting of lupus.
心血管（CV）事件是系统性红斑狼疮（SLE）患者死亡的一个重要原因，这是由于动脉粥样硬化加速所致。SLE 的病因是多因素的，仍不清楚；在其他潜在的罪魁祸首中，过度的 B 细胞激活似乎起着至关重要的作用。越来越多的证据支持 B 细胞在动脉粥样硬化发病机制中的作用。
本文重点介绍了 B 细胞和自身抗体在普通人群和狼疮人群的动脉粥样硬化发病机制中的作用。还对已发表的关于实验模型的文献进行了综述。
不同的 B 细胞亚群似乎对动脉粥样硬化的进展有不同的影响，B2 B 细胞表现出主要的动脉粥样硬化表型，而 B1 B 细胞主要被认为是动脉粥样硬化保护的。通过抗 B 细胞治疗选择性抑制 B2 似乎是一种很有前途的治疗策略，可以针对狼疮患者的动脉粥样硬化发展。
