Ollert M, Korting H C, Braun-Falco O
Dermatologische Klinik, Ludwig-Maximilians-Universität München.
Hautarzt. 1988 Aug;39(8):498-503.
The adherence of the pathogen to the host cell is the first and decisive step in Candida albicans infections of the human organism. The mechanisms involved are mostly examined in human epithelial cells which are newly exfoliated and which therefore have a limited life expectancy. In this case, the glycoproteins on the cell surface of Candida albicans--mainly the mannan--are of central importance. They are the main component of the fungus to adhere to the host cell as well as to bind and activate the serum complement. Finally, the role of mannan in the interaction with host defence mechanisms is stressed.
病原体对宿主细胞的黏附是白色念珠菌感染人体的首要且决定性步骤。所涉及的机制大多在新脱落因而寿命有限的人上皮细胞中进行研究。在这种情况下，白色念珠菌细胞表面的糖蛋白——主要是甘露聚糖——至关重要。它们是真菌黏附宿主细胞以及结合并激活血清补体的主要成分。最后，强调了甘露聚糖在与宿主防御机制相互作用中的作用。
