Duggan M J, Weisenburger D D, Sun N C, Purtilo D T
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.
Hematol Oncol Clin North Am. 1988 Dec;2(4):637-56.
We have summarized the findings in selected congenital and acquired immunodeficiency disorders that frequently display blood and bone marrow abnormalities. Many other immunodeficiency syndromes were not discussed, as bone marrow abnormalities are infrequently seen in them. Examination of the bone marrow is not usually critical for diagnosing most immunodeficiency disorders. However, it may be diagnostic in the evaluation of fever of unknown origin, to rule out other causes of peripheral cytopenias, and to screen for virus-associated malignancies frequently seen in immune-deficient patients (for example, B cell lymphoma, Kaposi's sarcoma). Examination of the bone marrow is critical in the diagnosis of the virus-associated hemophagocytic syndrome and is often important in evaluating patients with the acquired immunodeficiency syndromes who display hematologic disturbances, such as those being treated with AZT, or those who might have opportunistic infections or malignant neoplasms.
我们总结了一些常见的先天性和获得性免疫缺陷疾病的研究结果，这些疾病常表现出血液和骨髓异常。许多其他免疫缺陷综合征未作讨论，因为骨髓异常在其中并不常见。对于大多数免疫缺陷疾病的诊断，骨髓检查通常并非关键。然而，在评估不明原因发热、排除其他外周血细胞减少的原因以及筛查免疫缺陷患者中常见的病毒相关恶性肿瘤（例如，B细胞淋巴瘤、卡波西肉瘤）时，骨髓检查可能具有诊断价值。骨髓检查对于病毒相关噬血细胞综合征的诊断至关重要，并且在评估患有血液系统紊乱的获得性免疫缺陷综合征患者时通常也很重要，例如接受齐多夫定治疗的患者，或者可能患有机会性感染或恶性肿瘤的患者。
