Department of Internal Medicine, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.
Department of Internal Medicine, Bheri Hospital, Nepalgunj, Nepal.
JNMA J Nepal Med Assoc. 2021 Dec 11;59(244):1239-1242. doi: 10.31729/jnma.6318.
Hematologic abnormalities are among the most common complications of infection with Human Immunodeficiency Virus. These abnormalities are due to: impaired hematopoiesis, immune mediated cytopenias and altered coagulation mechanisms. Anemia is the most frequent,however, leukopenia, lymphopenia, and thrombocytopenia have also been observed. The aim of the study was to find the prevalence of anemia in patients attending anti-retroviral therapy at a tertiary care center of Nepal.
The study was a descriptive cross-sectional study conducted from August 2018 to August 2019 in patients attending anti-retroviral therapy at a tertiary care hospital. Ethical approval was obtained from the Institutional Review Board of National Academy of Medical Sciences before starting the study (Reference number 267). Convenient sampling was used for this study. Data were analysed using the Statistical package for Social Sciences version 20. Point estimate at 90% confidence interval was calculated along with frequency and proportion for the binary data.
The prevalence of anemia among patients attending anti-retroviral therapy centers in our study was found in 29 (58%) (46.55-69.45 at 90% Confidence Interval). Out of those patients, 20 (63%) were male and 9 (50%) were female. The mean hemoglobin value was 11.946±2.51g/dl.
The prevalence of anemia among patients attending antiretroviral therapy in our study was found to be high which is consistent with the findings of other similar international studies. These patients should be routinely monitored and treated for the occurrence of hematological abnormalities.
血液学异常是人类免疫缺陷病毒感染最常见的并发症之一。这些异常是由于：造血功能受损、免疫介导的细胞减少症和凝血机制改变。贫血是最常见的，但也观察到白细胞减少症、淋巴细胞减少症和血小板减少症。本研究的目的是在尼泊尔的一家三级保健中心发现接受抗逆转录病毒治疗的患者中贫血的患病率。
这是一项描述性的横断面研究，于 2018 年 8 月至 2019 年 8 月在一家三级医院接受抗逆转录病毒治疗的患者中进行。在开始研究之前，国家医学科学院机构审查委员会获得了伦理批准（参考号 267）。本研究采用方便抽样。使用社会科学统计软件包 20 版分析数据。计算了 90%置信区间的点估计值以及二进制数据的频率和比例。
在我们的研究中，接受抗逆转录病毒治疗中心的患者贫血患病率为 29 例（58%）（90%置信区间为 46.55-69.45）。在这些患者中，20 例（63%）为男性，9 例（50%）为女性。平均血红蛋白值为 11.946±2.51g/dl。
在我们的研究中，接受抗逆转录病毒治疗的患者贫血患病率较高，与其他类似的国际研究结果一致。这些患者应常规监测和治疗血液学异常。
