Hyun B H, Stevenson A J, Hanau C A
Department of Pathology, Jefferson Medical College, Philadelphia, Pennsylvania.
Hematol Oncol Clin North Am. 1994 Aug;8(4):651-63.
Bone marrow evaluation is an important and effective way of diagnosing and evaluating primary hematologic and metastatic neoplasms as well as nonhematologic disorders. Many variations exist for obtaining marrow samples (sites, instruments, techniques); however, the method outlined in this article has proven reliable. Complete evaluation of bone marrow samples should include a brief patient history, pertinent laboratory data, peripheral blood films, bone marrow aspirate smears and sections, and biopsy imprints and sections. Routine examination of the bone marrow as described previously is usually adequate for interpretation. However, application of additional studies using cytochemical, immunocytochemical, immunohistochemical, cytogenetic, and molecular techniques may prove to be of critical importance in the diagnosis of hematologic malignancies.
骨髓评估是诊断和评估原发性血液系统疾病、转移性肿瘤以及非血液系统疾病的重要且有效的方法。获取骨髓样本的方法有多种（部位、器械、技术）；然而，本文所述方法已被证明是可靠的。对骨髓样本的完整评估应包括简要的患者病史、相关实验室数据、外周血涂片、骨髓穿刺涂片和切片，以及活检印片和切片。如前所述，对骨髓进行常规检查通常足以做出诊断。然而，应用细胞化学、免疫细胞化学、免疫组织化学、细胞遗传学和分子技术进行额外研究，可能在血液系统恶性肿瘤诊断中具有至关重要的意义。
