Rudolf Virchow Center for Experimental Biomedicine , University of Würzburg , 97080 Würzburg , Germany.
Departamento de Bioquímica, Instituto de Química , Universidade de São Paulo , São Paulo 05508-000 , Brazil.
Chem Res Toxicol. 2019 Mar 18;32(3):362-369. doi: 10.1021/acs.chemrestox.8b00349. Epub 2019 Jan 31.
Ferroptosis is a form of cell death that requires phospholipid peroxidation and has attracted increased attention, both as a means to eradicate tumors resistant to standard chemotherapy and for its potential contribution to tissue damage such as in ischemia/reperfusion. The center stage taken by phospholipid peroxidation in ferroptosis is highlighted by recent discoveries that demonstrate an intricate regulation of both the metabolism of polyunsaturated fatty acids as well as mechanisms leading to their oxidation. These metabolic steps converge at the point of ferroptosis execution through mechanisms that are now only starting to be understood. In this short review, we provide an appraisal of some of the recent advances in the understanding of the ferroptosis process and also provide some perspectives of where this knowledge could take us.
铁死亡是一种需要磷脂过氧化的细胞死亡形式，它作为一种消除对标准化疗有抗性的肿瘤的手段，以及其对缺血/再灌注等组织损伤的潜在贡献，引起了越来越多的关注。最近的发现强调了磷脂过氧化在铁死亡中的核心作用，这些发现表明多不饱和脂肪酸代谢以及导致其氧化的机制受到了复杂的调节。这些代谢步骤通过目前才刚刚开始被理解的机制在铁死亡执行点汇聚。在这篇简短的综述中，我们对铁死亡过程理解的一些最新进展进行了评估，并对这些知识可能带来的方向提供了一些观点。
