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阿得米罗尔联合透明质酸钠对小鼠脊髓损伤后膀胱变化具有有益作用。

The association of adelmidrol with sodium hyaluronate displays beneficial properties against bladder changes following spinal cord injury in mice.

机构信息

University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Messina, Italy.

Saint Louis University School of Medicine, Department of Pharmacological and Physiological Science, Saint Louis, United States of America.

出版信息

PLoS One. 2019 Jan 17;14(1):e0208730. doi: 10.1371/journal.pone.0208730. eCollection 2019.

DOI:10.1371/journal.pone.0208730
PMID:30653511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6336272/
Abstract

The disruption of coordinated control between the brain, spinal cord and peripheral nervous system caused by spinal cord injury (SCI) leads to several secondary pathological conditions, including lower urinary tract dysfunction. In fact, urinary tract dysfunction associated with SCI is urinary dysfunction could be a consequence of a lack of neuroregeneration of supraspinal pathways that control bladder function. The object of the current research was to explore the effects of adelmidrol + sodium hyaluronate, on bladder damage generated after SCI in mice. Spinal cord was exposed via laminectomy, and SCI was induced by extradural compression at T6 to T7 level, by an aneurysm clip with a closing force of 24 g. Mice were treated intravesically with adelmidrol + sodium hyaluronate daily for 48 h and 7 days after SCI. Adelmidrol + sodium hyaluronate reduced significantly mast cell degranulation and down-regulated the nuclear factor-κB pathway in the bladder after SCI both at 48 h and 7days. Moreover, adelmidrol + sodium hyaluronate reduced nerve growth factor expression, suggesting an association between neurotrophins and bladder pressure. At 7 days after SCI, the bladder was characterized by a marked bacterial infection and proteinuria; surprisingly, adelmidrol + sodium hyaluronate reduced significantly both parameters. These data show the protective roles of adelmidrol + sodium hyaluronate on bladder following SCI, highlighting a potential therapeutic target for the reduction of bladder changes.

摘要

脊髓损伤 (SCI) 导致大脑、脊髓和外周神经系统之间的协调控制中断，引发多种继发性病理状况，包括下尿路功能障碍。事实上，与 SCI 相关的尿路功能障碍可能是由于缺乏对膀胱功能进行控制的中枢神经通路的神经再生所致。本研究的目的是探讨 Adelmidrol+透明质酸钠对 SCI 后小鼠膀胱损伤的影响。通过椎板切除术暴露脊髓，并通过动脉瘤夹在 T6 至 T7 水平进行硬膜外压迫来诱导 SCI，夹闭力为 24g。在 SCI 后 48 小时和 7 天，通过膀胱内给予 Adelmidrol+透明质酸钠进行治疗。 Adelmidrol+透明质酸钠可显著减少 SCI 后膀胱肥大细胞脱颗粒，并在 48 小时和 7 天时下调核因子-κB 通路。此外， Adelmidrol+透明质酸钠可降低神经生长因子的表达，提示神经营养因子与膀胱压力之间存在关联。在 SCI 后 7 天，膀胱表现出明显的细菌感染和蛋白尿；令人惊讶的是， Adelmidrol+透明质酸钠可显著降低这两个参数。这些数据表明 Adelmidrol+透明质酸钠对 SCI 后膀胱具有保护作用，突出了减少膀胱变化的潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/b1a1e5a091ce/pone.0208730.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/4c9f5f9d7b96/pone.0208730.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/93d1a58089c4/pone.0208730.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/34da6e871656/pone.0208730.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/0a63e6728742/pone.0208730.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/fc935b7b03c1/pone.0208730.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/5830f1009a16/pone.0208730.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/057fc22b063a/pone.0208730.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/535c65c0d232/pone.0208730.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/b1a1e5a091ce/pone.0208730.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/4c9f5f9d7b96/pone.0208730.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/93d1a58089c4/pone.0208730.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/34da6e871656/pone.0208730.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/0a63e6728742/pone.0208730.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/fc935b7b03c1/pone.0208730.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/5830f1009a16/pone.0208730.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/057fc22b063a/pone.0208730.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/535c65c0d232/pone.0208730.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/887b/6336272/b1a1e5a091ce/pone.0208730.g009.jpg

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