The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
PLoS One. 2019 Jan 17;14(1):e0210832. doi: 10.1371/journal.pone.0210832. eCollection 2019.
To study if retinopathy increases the risk of stroke recurrence in stroke patients with type 2 diabetes. Also, to study if stroke patients with type 2 diabetes have an increased risk of stroke recurrence compared to non-diabetics and if stroke patients with type 2 diabetes, regardless of retinopathy, have a higher incidence of carotid stenosis. Also, to study if stroke patients with type 2 diabetes retinopathy have increased incidence of carotid stenosis.
We included 445 patients with type 2 diabetes mellitus and a matched control group of 445 patients without diabetes, who had all suffered their first stroke or TIA. Information on retinopathy, risk factors and stroke recurrence were obtained from registers and medical records.
Retinopathy did not increase the risk of stroke recurrence in diabetes patients, HR 0.89 (0.51-1.53), p = 0.67. The risk of stroke recurrence was not increased in diabetics compared to non-diabetes. Diabetes patients had an increased prevalence of carotid stenosis compared to non-diabetics, 1.69 (1.15-2.48), p = 0.008. The prevalence of carotid stenosis in diabetics with retinopathy was not increased compared to diabetics without retinopathy.
Retinopathy is not a predictor of stroke recurrence or carotid stenosis in type 2 diabetes patients.
研究 2 型糖尿病卒中患者的视网膜病变是否会增加卒中复发的风险。同时，研究与非糖尿病患者相比，2 型糖尿病卒中患者是否有更高的卒中复发风险，以及无论是否存在视网膜病变，2 型糖尿病卒中患者是否有更高的颈动脉狭窄发生率。此外，还研究了 2 型糖尿病视网膜病变的卒中患者是否有更高的颈动脉狭窄发生率。
我们纳入了 445 例 2 型糖尿病患者和 445 例匹配的无糖尿病对照组患者，他们均首次发生卒中或 TIA。从登记处和病历中获取有关视网膜病变、危险因素和卒中复发的信息。
视网膜病变并未增加糖尿病患者卒中复发的风险，HR 0.89（0.51-1.53），p=0.67。与非糖尿病患者相比，糖尿病患者的卒中复发风险并未增加。与非糖尿病患者相比，糖尿病患者的颈动脉狭窄患病率更高，1.69（1.15-2.48），p=0.008。与无视网膜病变的糖尿病患者相比，有视网膜病变的糖尿病患者的颈动脉狭窄患病率并未增加。
视网膜病变不是 2 型糖尿病患者卒中复发或颈动脉狭窄的预测因素。
