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PEO-b-PPO 星型聚合物增强了静电耦合脂质体/聚电解质复合物的结构稳定性。

PEO-b-PPO star-shaped polymers enhance the structural stability of electrostatically coupled liposome/polyelectrolyte complexes.

机构信息

Institute of Physical Chemistry, RWTH Aachen University, Aachen, Germany.

Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation.

出版信息

PLoS One. 2019 Jan 17;14(1):e0210898. doi: 10.1371/journal.pone.0210898. eCollection 2019.

DOI:10.1371/journal.pone.0210898
PMID:30653618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6336312/
Abstract

We propose a strategy to counteract the salt-driven disassembly of multiliposomal complexes made by electrostatic co-assembly of anionic small unilamellar liposomes and cationic star-shaped polyelectrolytes (made of quaternized poly(dimethylaminoethyl methacrylate) (qPDMAEMA100)3.1). The combined action of (qPDMAEMA100)3.1 and a nonionic star-shaped polymer (PEO12-b-PPO45)4, which comprises diblock copolymer arms uniting a poly(ethylene oxide) PEO inner block and a poly(propylene oxide) PPO terminal block, leads to a stabilization of these complexes against disintegration in saline solutions. Hereby, the anchoring of the PPO terminal blocks to the lipid bilayer and the bridging between several liposomes are at the origin of the promoted structural stability. Two-focus fluorescence correlation spectroscopy verifies the formation of multiliposomal complexes with (PEO12-b-PPO45)4. The polyelectrolyte and the amphiphilic polymer work synergistically, as the joint action still assures some membrane integrity, which is not seen for the mere (PEO12-b-PPO45)4-liposome interaction alone.

摘要

我们提出了一种策略来对抗由阴离子小单层脂质体和阳离子星形聚合物（由季铵化聚（二甲基氨基乙基甲基丙烯酸酯）（qPDMAEMA100）3.1 制成）静电共组装而成的多脂质体复合物在盐驱动下的解体。（qPDMAEMA100）3.1 和一种非离子星形聚合物（PEO12-b-PPO45）4 的联合作用，后者由将聚（氧化乙烯）PEO 内嵌段和聚（氧化丙烯）PPO 末端嵌段连接在一起的嵌段共聚物臂组成，导致这些复合物在盐溶液中稳定，不易解体。由此，PPO 末端嵌段与脂质双层的锚定以及几个脂质体之间的桥接是促进结构稳定性的原因。双焦点荧光相关光谱法验证了（PEO12-b-PPO45）4 形成的多脂质体复合物。聚电解质和两亲聚合物协同作用，因为联合作用仍确保了一些膜的完整性，而仅仅（PEO12-b-PPO45）4-脂质体相互作用则不会看到这种情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d205/6336312/a10b05d5a93f/pone.0210898.g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d205/6336312/34f289343523/pone.0210898.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d205/6336312/a10b05d5a93f/pone.0210898.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d205/6336312/1e42e5a84647/pone.0210898.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d205/6336312/ad93516c5333/pone.0210898.g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d205/6336312/191584399864/pone.0210898.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d205/6336312/cf959f0f06d1/pone.0210898.g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d205/6336312/a5830e6195db/pone.0210898.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d205/6336312/34f289343523/pone.0210898.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d205/6336312/a10b05d5a93f/pone.0210898.g009.jpg

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