National Atomic Energy Commission of Argentina (CNEA), National Research Council of Argentina (CONICET), Department of Radiobiology, Av. General Paz 1499 (1650), San Martín, Buenos Aires, Argentina.
National Atomic Energy Commission of Argentina (CNEA), National Research Council of Argentina (CONICET), Department of Radiobiology, Av. General Paz 1499 (1650), San Martín, Buenos Aires, Argentina.
Mol Cell Endocrinol. 2019 Mar 1;483:64-73. doi: 10.1016/j.mce.2019.01.006. Epub 2019 Jan 14.
The use of Bisphenol S (BPS) was proposed as an alternative to Bisphenol A (BPA), a chemical employed in the production of polycarbonate plastics and epoxy resins. BPA is a xenoestrogen that affects normal physiology in several species. It was reported that BPS may also act as a xenoestrogen with harmful effects in the reproductive system. Here we studied the effects of BPS during the induction of a polycystic ovarian syndrome (PCOS)-like condition in rats. Animals were injected daily with vehicle, DHEA 60 mg/kg, BPS 1 μg/kg and DHEA-BPS, for 20 days. Cell apoptosis, cell proliferation, and EZRIN expression were analyzed by immunohistochemistry. We found an increase in PCNA expression, which correlates with cytoplasmic accumulation of the polarization marker, EZRIN, in the BPS treated groups. Additionally, the administration of BPS in the DHEA treated group augmented the stratification and number of "intraepithelial lumina" in the endometrial surface epithelium.
双酚 S（BPS）的使用被提议作为双酚 A（BPA）的替代品，BPA 是一种用于生产聚碳酸酯塑料和环氧树脂的化学物质。BPA 是一种外源性雌激素，会影响多种物种的正常生理机能。有报道称，BPS 也可能作为一种具有生殖系统有害影响的外源性雌激素。在这里，我们研究了 BPS 在诱导大鼠多囊卵巢综合征（PCOS）样病症中的作用。动物每天接受 vehicle、DHEA 60mg/kg、BPS 1μg/kg 和 DHEA-BPS 注射，共 20 天。通过免疫组织化学分析细胞凋亡、细胞增殖和 EZRIN 表达。我们发现 PCNA 表达增加，这与极化标记物 EZRIN 的细胞质积累相关，在 BPS 处理组中。此外，在 DHEA 处理组中给予 BPS 会增加子宫内膜表面上皮的“上皮内腔”分层和数量。
