Department of Medical Biology, Faculty of Health Sciences, University of Warmia and Mazury in Olsztyn, Żołnierska 14C str., 10-561 Olsztyn, Poland.
Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego Str. 13, 10-718 Olsztyn, Poland.
Nutrients. 2020 Feb 19;12(2):532. doi: 10.3390/nu12020532.
In recent years, bisphenol analogues such as bisphenol S (BPS) have come to replace bisphenol A in food packaging and food containers, since bisphenol A (BPA) has been shown to leach into food and water, causing numerous negative health effects. Unfortunately, little or no research was done to determine the safety of these BPA-free products before they were marketed to the public as a healthier alternative. The latest studies have shown that some of these bisphenol analogues may be even more harmful than the original BPA in some situations. This article used a literature survey to investigate the bisphenol analogue BPS and compare it to BPA and other analogues with regards to increased obesity, metabolic disorders, cancer, and reproductive defects; among others. It was found that BPS works via different pathways than does BPA while causing equivalent obesogenic effects, such as activating preadipocytes, and that BPS was correlated with metabolic disorders, such as gestational diabetes, that BPA was not correlated with. BPS was also shown to be more toxic to the reproductive system than BPA and was shown to hormonally promote certain breast cancers at the same rate as BPA. Therefore, a strong argument may be made to regulate BPS in exactly the same manner as BPA.
近年来，双酚类似物如双酚 S（BPS）已取代双酚 A（BPA）用于食品包装和食品容器，因为 BPA 已被证明会浸出到食物和水中，导致许多负面健康影响。不幸的是，在将这些无 BPA 产品推向市场作为更健康的替代品之前，几乎没有或根本没有进行研究来确定它们的安全性。最新的研究表明，在某些情况下，这些双酚类似物中的一些可能比原始的 BPA 更有害。本文通过文献调查研究了双酚类似物 BPS，并将其与 BPA 和其他类似物进行了比较，涉及肥胖、代谢紊乱、癌症和生殖缺陷等方面。研究发现，BPS 通过与 BPA 不同的途径发挥作用，同时产生等效的致肥胖作用，例如激活前体脂肪细胞，并且 BPS 与代谢紊乱（如妊娠糖尿病）相关，而 BPA 则没有相关性。BPS 对生殖系统的毒性也比 BPA 更大，并显示出与 BPA 相同的速率促进某些乳腺癌的发生。因此，可以强有力地主张以与 BPA 完全相同的方式对 BPS 进行监管。
