Blank H J, Brinkmann O H, Berndt V
MMW Munch Med Wochenschr. 1978 May 19;120(20):693-8.
Different Therapy of Bromisoval Poisoning and Primary Detoxication by Gastrotomy or Duodenotomy: Bromisoval poisoning is encumbered with a high complication rate and mortality. Primary and secondary detoxication methods differ in efficacy and risk of the method. Primary detoxication deserves prefrence because it terminates the invasion of the poison, the duration of coma is shortened and complications due to poisoning are eliminated. An extremely effective, and at the same time involving little risk, primary detoxication can be undertaken by gastrotomy or duodenotomy, because the tablet substances remain visible for a long time as radiopaque conglomerates in the stomach and suprapapillary duodenum. In 5 cases with 30 to 70 g carbamide, the duration of the coma was cut by more than half compared with 25 equally severe poisoning treated in the usual manner.
溴米那中毒的并发症发生率和死亡率很高。初级和次级解毒方法在疗效和方法风险方面存在差异。初级解毒值得优先考虑,因为它能终止毒物的侵入,缩短昏迷持续时间并消除中毒引起的并发症。通过胃切开术或十二指肠切开术可以进行一种极其有效且同时风险极小的初级解毒,因为片剂物质在胃和十二指肠乳头上方会作为不透射线的聚集体长时间保持可见。在5例摄入30至70克溴米那的病例中,与25例以常规方式治疗的同等严重中毒病例相比,昏迷持续时间缩短了一半以上。