Chae Yun Jeong, Joe Han Bum, Oh Juyeon, Lee Eunyoung, Yi In Kyong
Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon 16499, Korea.
Department of Biomedical Informatics, Ajou University School of Medicine, Suwon 16499, Korea.
J Clin Med. 2019 Jan 16;8(1):97. doi: 10.3390/jcm8010097.
Sugammadex rapidly reverses muscle relaxation compared to acetylcholinesterase inhibitors. The long-term outcomes of sugammadex, however, are not well known. We compared 30-day postoperative outcomes following sugammadex and acetylcholinesterase inhibitor use in colorectal surgery patients.
Colorectal surgical patients older than 21 were included in this retrospective study, and were dichotomized according to use of reversal agents, sugammadex (group S), and acetylcholinesterase inhibitor (group A). We assessed 30-day postoperative outcomes, including total length of hospital stay, length of postoperative hospital stay, readmission rate, and delayed discharge rate. Additional parameters included postanesthetic care unit stay time, time to first successful oral intake, unforeseen intensive care unit (ICU) admission rate, postoperative pulmonary complications, and mortality.
Among a total of 585 patients, 157 patients remained in each group after propensity score matching. Total length of hospital stay, length of postoperative hospital stay, and readmission rates did not differ between the two groups, while the incidence of delayed discharge was significantly lower in group S (23 (15%) vs. 40 (25%), = 0.017). Other outcomes did not differ between the two groups.
We found no difference in 30-day postoperative outcomes following sugammadex and acetylcholinesterase inhibitor use. The only difference between these treatments was the associated incidence of delayed discharge, which was lower in group S.
与乙酰胆碱酯酶抑制剂相比，舒更葡糖能迅速逆转肌肉松弛。然而，舒更葡糖的长期疗效尚不清楚。我们比较了结直肠手术患者使用舒更葡糖和乙酰胆碱酯酶抑制剂后的术后30天结局。
本回顾性研究纳入了年龄大于21岁的结直肠手术患者，并根据使用的逆转剂分为两组，即舒更葡糖组（S组）和乙酰胆碱酯酶抑制剂组（A组）。我们评估了术后30天的结局，包括总住院时间、术后住院时间、再入院率和延迟出院率。其他参数包括麻醉后护理单元停留时间、首次成功经口进食时间、意外入住重症监护病房（ICU）的发生率、术后肺部并发症和死亡率。
在总共585例患者中，倾向评分匹配后每组各有157例患者。两组之间的总住院时间、术后住院时间和再入院率没有差异，而S组的延迟出院发生率显著更低（23例（15%）对40例（25%），P = 0.017）。两组之间的其他结局没有差异。
我们发现使用舒更葡糖和乙酰胆碱酯酶抑制剂后的术后30天结局没有差异。这些治疗之间的唯一差异是延迟出院的相关发生率，S组更低。
