Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China.
Biomolecules. 2019 Jan 16;9(1):30. doi: 10.3390/biom9010030.
Cembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring. They have gained wide interest in recent years and are a major hotspot in the research of natural product chemistry. Since 1962, various tobacco cembranoid diterpenes have been identified. This review systematically discusses and summarises the excellent antimicrobial, insecticidal, cytotoxic and neuroprotective activities of tobacco cembranoid diterpenes. These compounds show potential to be developed as botanical fungicides, cytotoxic drugs and drugs for the treatment of human immunodeficiency virus, Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. However, there are relatively few studies on the structure⁻activity relationship (SAR) of tobacco cembranoid diterpenes. Therefore, future studies should focus on their structural modification, SAR and biogenic relationships.
贝壳杉烯类化合物是由四个异戊二烯单元组成的碳环二萜类化合物，是具有母体骨架由 14 个环组成的天然产物。近年来，它们引起了广泛的关注，成为天然产物化学研究的一个主要热点。自 1962 年以来，已经鉴定出各种烟草贝壳杉烯二萜类化合物。本文系统地讨论和总结了烟草贝壳杉烯二萜类化合物具有优异的抗菌、杀虫、细胞毒性和神经保护活性。这些化合物具有开发为植物性杀菌剂、细胞毒性药物以及治疗人类免疫缺陷病毒、阿尔茨海默病、帕金森病和其他神经退行性疾病药物的潜力。然而，关于烟草贝壳杉烯二萜类化合物的结构-活性关系（SAR）的研究相对较少。因此，未来的研究应集中在它们的结构修饰、SAR 和生物发生关系上。
