源自克里特岩蔷薇树脂“拉达诺”的新型半合成抗菌半日花烷型二萜类化合物。

New semisynthetic antimicrobial labdane-type diterpenoids derived from the resin "ladano" of Cistus creticus.

作者信息

Kalpoutzakis E, Aligiannis N, Mitaku S, Chinou I, Harvala C, Skaltsounis A L

机构信息

Laboratory of Pharmacognosy, University of Athens, Panepistimiopolis, Zografou, Athens, Greece.

出版信息

Z Naturforsch C J Biosci. 2001 Jan-Feb;56(1-2):49-52. doi: 10.1515/znc-2001-1-209.

DOI:10.1515/znc-2001-1-209

PMID:11302213

Abstract

The antimicrobial activity of fifteen semisynthetic labdane-type diterpenes derived from the two major natural compounds 3 and 4 of the resin "ladano" of Cistus creticus is reported. The chloroethyl carbamidic esters 15 and 20 showed the strongest antimicrobial activity against Gram(+), Gram(-) bacteria and pathogenic fungi.

摘要

据报道，从岩蔷薇树脂“拉达诺”的两种主要天然化合物3和4衍生而来的15种半合成半日花烷型二萜类化合物具有抗菌活性。氯乙基氨基甲酸酯15和20对革兰氏阳性菌、革兰氏阴性菌和致病真菌表现出最强的抗菌活性。