Skibinska Maria, Kapelski Pawel, Rajewska-Rager Aleksandra, Szczepankiewicz Aleksandra, Narozna Beata, Duda Joanna, Dmitrzak-Weglarz Monika, Twarowska-Hauser Joanna, Pawlak Joanna
a Psychiatric Genetics Unit, Department of Psychiatry , Poznan University of Medical Sciences , Poznan , Poland.
b Laboratory of Molecular and Cell Biology , Poznan University of Medical Sciences , Poznan , Poland.
Nord J Psychiatry. 2019 Feb;73(2):96-103. doi: 10.1080/08039488.2018.1563213. Epub 2019 Jan 17.
Neurotrophin-3 (NTF3) and neurotrophin-4 (NTF4) play a crucial role in the neurodevelopment, differentiation, survival, and protection of neurons in different brain regions. Schizophrenia and depression are highly associated with metabolic abnormalities. Longitudinal and cross-sectional comparisons of NTF3 and NTF4 levels, as well as clinical and metabolic parameters, were studied in schizophrenia, first-episode depression, and control groups.
Serum NTF3 and NTF4 levels, body mass index (BMI), fasting serum glucose and lipid profile: cholesterol, triglyceride, high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) were measured at baseline and week 8 in 133 women: 55 patients with schizophrenia (19 with first-episode and 36 chronic), 30 patients with a first-episode depression and 48 healthy controls. The severity of the symptoms was evaluated with the Positive and Negative Syndrome Scale, 17-item Hamilton Depression Rating Scale and the Beck Depression Inventory.
Longitudinal and cross-sectional comparisons did not detect any differences in the serum levels of NTF3 and NTF4 between studied groups. NTF3 and NTF4 levels were strongly correlated. Correlation of NTF3 and HDL-C levels at baseline was observed. Significant changes in cholesterol and fasting serum glucose levels in first-episode depression patients during 8 weeks of treatment were detected. Significant differences in BMI and LDL-C levels between schizophrenia and first-episode depression patients were discovered.
To our knowledge, this is the first research which correlates NTF3 and NTF4 with metabolic parameters. Our study does not support the theory that the peripheral levels of NTF3 and NTF4 are disturbed in schizophrenia or first-episode depression.
神经营养因子-3（NTF3）和神经营养因子-4（NTF4）在不同脑区神经元的神经发育、分化、存活及保护中发挥关键作用。精神分裂症和抑郁症与代谢异常高度相关。本研究对精神分裂症患者、首发抑郁症患者及对照组的NTF3和NTF4水平以及临床和代谢参数进行了纵向和横向比较。
对133名女性进行研究，在基线和第8周时测量血清NTF3和NTF4水平、体重指数（BMI）、空腹血糖及血脂谱：胆固醇、甘油三酯、高密度脂蛋白（HDL-C）和低密度脂蛋白（LDL-C）。其中55例精神分裂症患者（19例首发，36例慢性），30例首发抑郁症患者，48例健康对照。采用阳性和阴性症状量表、17项汉密尔顿抑郁量表及贝克抑郁量表评估症状严重程度。
纵向和横向比较未发现研究组间血清NTF3和NTF4水平存在差异。NTF3和NTF4水平呈强相关。观察到基线时NTF3与HDL-C水平存在相关性。检测到首发抑郁症患者在治疗8周期间胆固醇和空腹血糖水平有显著变化。发现精神分裂症患者与首发抑郁症患者在BMI和LDL-C水平上存在显著差异。
据我们所知，这是第一项将NTF3和NTF4与代谢参数相关联的研究。我们的研究不支持精神分裂症或首发抑郁症患者外周血中NTF3和NTF4水平紊乱的理论。
