Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W 168th Street, 16th Floor, New York, NY 10032, USA.
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Columbia University Medical Center, 5 Columbus Circle, PH New York, NY 10019, USA.
Semin Perinatol. 2019 Mar;43(2):116-120. doi: 10.1053/j.semperi.2018.12.009. Epub 2018 Dec 20.
Miscarriage is a frequent outcome seen in obstetrics with 1 in 5 pregnancies ending in an early pregnancy loss. Aneuploidy is the most significant single factor affecting early pregnancy failure and miscarriage. The risk of aneuploidy increases significantly with increasing maternal age. There has been tremendous advancement in technology that has made preimplantation genetic testing for aneuploidy reliable and accessible. For women in their mid-to-late 30s there is great utility in the use of PGT-A to facilitate single embryo transfer, reduce the risk of clinical miscarriage and ongoing aneuploidy gestations. The current data supports use of preimplantation genetic testing for aneuploidy and single embryo transfer for this population of women. At this time, more prospective data is needed to determine the effect of preimplantation genetic testing for aneuploidy on rates of miscarriage in the recurrent pregnancy loss population.
流产是妇产科常见的结局，5 次妊娠中就有 1 次以早期妊娠丢失告终。非整倍体是影响早期妊娠失败和流产的最重要单一因素。随着母亲年龄的增长，非整倍体的风险显著增加。技术的巨大进步使得胚胎植入前非整倍体检测变得可靠且易于获得。对于年龄在 35 岁中后期的女性来说，PGT-A 的使用具有很大的实用性，可以促进单胚胎移植，降低临床流产和持续性非整倍体妊娠的风险。目前的数据支持对这部分女性使用胚胎植入前非整倍体检测和单胚胎移植。此时，需要更多的前瞻性数据来确定胚胎植入前非整倍体检测对复发性流产人群流产率的影响。
