Instituto de Fertilidad Humana - Inser Bogotá, Colombia.
Clínica del Country - Bogotá, Colombia.
JBRA Assist Reprod. 2022 Apr 17;26(2):280-287. doi: 10.5935/1518-0557.20210085.
To analyze the results of the preimplantation genetic testing for aneuploidy at the Instituto de Fertilidad Humana - Inser Bogotá, Colombia, from 2016 to 2020.
This study is an observational, retrospective, and correlative analysis of biopsies from 319 embryos (from 54 patients) submitted to preimplantation genetic testing for aneuploidy by different molecular techniques.
Of the 54 patients included in the study, 42 provided their own oocytes, and 12 used donated oocytes. The main indication to perform the preimplantation genetic testing was advanced maternal age. We obtained 319 embryos: Ninety-one (28.5%) euploid, 197 (61.8%) aneuploid and 31 (9.7%) with no detectable DNA. The highest rate of aneuploid embryos was found in patients over 40 years (72.7%), and the euploidy rate in patients under 35 years was 37.1%. After the transfer of euploid embryos, the rates for implantation, ongoing pregnancy, live birth, and miscarriage were 40%, 50%, 40.6%, and 0%, respectively. Older maternal age correlated with higher numbers of aneuploid embryos and lower numbers of both euploid and 5-day embryos.
There was a positive correlation between maternal age and aneuploidy rate. Complex chromosomal abnormalities were the most frequent aneuploidies, followed by mosaicism and double aneuploidies. The miscarriage rate after the transfer of euploid embryos was 0 %.
分析 2016 年至 2020 年期间哥伦比亚波哥大人类生育研究所（Instituto de Fertilidad Humana - Inser）的胚胎植入前遗传学检测非整倍体的结果。
这是一项对 319 个胚胎（来自 54 名患者）的活检进行的观察性、回顾性和相关性分析，这些胚胎通过不同的分子技术进行了胚胎植入前遗传学检测非整倍体。
在 54 名入组患者中，42 名患者提供了自身卵子，12 名患者使用了捐赠卵子。进行胚胎植入前遗传学检测非整倍体的主要指征是高龄产妇。我们获得了 319 个胚胎：91 个（28.5%）为整倍体，197 个（61.8%）为非整倍体，31 个（9.7%）无可检测的 DNA。40 岁以上患者的非整倍体胚胎比例最高（72.7%），而 35 岁以下患者的整倍体率为 37.1%。在移植整倍体胚胎后，其着床率、持续妊娠率、活产率和流产率分别为 40%、50%、40.6%和 0%。产妇年龄越大，非整倍体胚胎的数量越多，整倍体和 5 天胚胎的数量越少。
产妇年龄与非整倍体率呈正相关。复杂染色体异常是非整倍体中最常见的，其次是嵌合体和双非整倍体。移植整倍体胚胎后的流产率为 0%。
