Furui Tatsuro, Takai Yasushi, Kimura Fuminori, Kitajima Michio, Nakatsuka Mikiya, Morishige Ken-Ichiro, Higuchi Akiko, Shimizu Chikako, Ozawa Miwa, Ohara Akira, Tatara Ryohei, Nakamura Terukazu, Horibe Keizo, Suzuki Nao
Department of Obstetrics and Gynecology Gifu University Graduate School of Medicine Gifu Japan.
Department of Obstetrics and Gynecology, Saitama Medical Center Saitama Medical University Kawagoe Japan.
Reprod Med Biol. 2018 Nov 20;18(1):105-110. doi: 10.1002/rmb2.12255. eCollection 2019 Jan.
This study aimed to evaluate the current status of reproductive disorders as long-term complications in adolescent and young adult (AYA) cancer patients by comparing survivors of childhood-onset with those of AYA-onset cancer in Japan.
We conducted a national survey of AYA cancer survivors and healthy AYAs and analyzed the results from survivors who underwent chemotherapy and reported fertility problems as their current concern.
Among all of the childhood-onset survivors, 27 (35.5%; nine males [28.1%] and 18 females [40.9%]) listed reproduction fertility problems as their current concern. Among all AYA-onset survivors, 25 (69.5%; 1/4 males [25.0%] and 24/32 females [75.0%]) listed these problems as a current concern. In contrast, 96.3% (26/27) of all childhood-onset cancer survivors and 68.0% (17/25) of all AYA-onset cancer survivors who received chemotherapy listed these problems as a current concern.
A considerable number of both childhood-onset and AYA-onset cancer survivors, and especially those who had undergone chemotherapy, reported reproductive dysfunction as a delayed complication. It is vitally important to establish a supportive care system both for the patients whose fertility was abolished after the completion of cancer treatment and prophylactically for patients before they begin treatment.
本研究旨在通过比较日本儿童期发病癌症幸存者与青少年及青年期（AYA）发病癌症幸存者，评估生殖系统疾病作为青少年及青年期癌症患者长期并发症的现状。
我们对青少年及青年期癌症幸存者和健康的青少年及青年进行了全国性调查，并分析了接受化疗且报告目前关注生育问题的幸存者的结果。
在所有儿童期发病的幸存者中，27人（35.5%；9名男性[28.1%]和18名女性[40.9%]）将生殖生育问题列为目前关注的问题。在所有青少年及青年期发病的幸存者中，25人（69.5%；4名男性中的1名[25.0%]和32名女性中的24名[75.0%]）将这些问题列为目前关注的问题。相比之下，所有接受化疗的儿童期发病癌症幸存者中有96.3%（26/27）和所有青少年及青年期发病癌症幸存者中有68.0%（17/25）将这些问题列为目前关注的问题。
相当数量的儿童期发病和青少年及青年期发病的癌症幸存者，尤其是那些接受过化疗的幸存者，报告生殖功能障碍是一种延迟性并发症。为癌症治疗结束后生育能力被消除的患者以及在开始治疗前预防性地为患者建立支持性护理系统至关重要。
