Takae Seido, Suzuki Nao
Department of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki City Japan.
Reprod Med Biol. 2019 Apr 8;18(3):217-224. doi: 10.1002/rmb2.12268. eCollection 2019 Jul.
As a result of recent developments in cancer treatment, cancer survivorship and survivors' quality of life have been emphasized. Although ovarian tissue cryopreservation (OTC) is an experimental technique, it would be the sole technique for fertility preservation treatment for girls with malignant disease. Indeed, OTC requires ovarian tissue transplantation (OTT) for conception. As for OTC, there is room to investigate OTT. The present review focused on the current state and progress of OTT.
The literature regarding OTT, which is currently under development, was reviewed.
To improve the outcome of OTT, both efficacy and safety are important. Good surgical technique and the optimal site are important surgical factors, with orthotopic transplantation increasing. Treatment of growth factors, gonadotropins, antioxidants, apoptosis suppression factors, and cell therapy may improve the efficacy of OTT by inducing neo-angiogenesis and preventing damage. Artificial ovaries, complete in vitro primordial follicle culture technique, and non-invasive ovarian imaging techniques, such as optical coherence tomography, to select the best ovarian tissue are future possibilities.
Improving neo-angiogenesis and preventing damage with optimization, as well as investigation of future techniques, may bring us to the next stage of a fertility preservation strategy.
由于癌症治疗的最新进展，癌症幸存者及其生活质量受到了重视。尽管卵巢组织冷冻保存（OTC）是一项实验性技术，但它将是患有恶性疾病女孩生育力保存治疗的唯一技术。实际上，OTC需要进行卵巢组织移植（OTT）才能受孕。关于OTC，OTT仍有研究空间。本综述聚焦于OTT的现状与进展。
对目前正在开展的有关OTT的文献进行综述。
为提高OTT的效果，疗效和安全性都很重要。良好的手术技术和最佳移植部位是重要的手术因素，原位移植的应用正在增加。生长因子、促性腺激素、抗氧化剂、凋亡抑制因子的治疗以及细胞疗法可能通过诱导新生血管形成和预防损伤来提高OTT的疗效。人工卵巢、完整的体外原始卵泡培养技术以及非侵入性卵巢成像技术，如光学相干断层扫描，用于选择最佳卵巢组织，这些都是未来的可能性。
通过优化提高新生血管形成和预防损伤，以及对未来技术的研究，可能会使我们进入生育力保存策略的下一阶段。
