纳米考布他汀穿过血脑肿瘤屏障后脑部血流的磁共振成像监测
MRI Monitoring of Cerebral Blood Flow after the Delivery of Nanocombretastatin across the Blood Brain Tumor Barrier.
作者信息
Gonawala Sunalee, Aryal Madhava, Ewing James R, deCarvalho Ana C, Kalkanis Steven, Ali Meser M
机构信息
Department of Neurosurgery, Cellular and Molecular Imaging Laboratory, Henry Ford Hospital, USA.
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA.
出版信息
J Nanomed Nanotechnol. 2018;9(5). doi: 10.4172/2157-7439.1000516. Epub 2018 Oct 25.
Introduction of polymeric nanoparticles in cancer therapeutics is widely investigated since nanomedicine often enables the intratumoral delivery of drugs with increased efficacy with minimal side effects. In this study MRI monitoring was employed to study the therapeutic effect of nanocombretastatin (G3-CA4) in an orthotopic glioma model. Water insoluble combretastatin (CA4) was conjugated to a small-sized water soluble G3-succinamic acid PAMAM dendrimer. Nanoconstruct sizes were determined by TEM to be 3 to 5 nm. Intravenous (i.v.) delivery of G3-CA4 in an orthotopic glioma model produced a long-lived ischemia accompanied by necrosis at the core of the tumor but leaving a rim of viable tissue. In contrast, delivery of CA4 alone has no therapeutic effect in an experimental rat model of glioma.
由于纳米医学通常能够在肿瘤内递送药物，提高疗效并减少副作用，因此聚合物纳米颗粒在癌症治疗中的应用受到广泛研究。在本研究中，采用磁共振成像（MRI）监测纳米考布他汀（G3-CA4）在原位胶质瘤模型中的治疗效果。将水不溶性考布他汀（CA4）与小尺寸水溶性G3-琥珀酰胺酸聚酰胺-胺（PAMAM）树枝状大分子偶联。通过透射电子显微镜（TEM）测定纳米构建体的尺寸为3至5纳米。在原位胶质瘤模型中静脉注射（i.v.）G3-CA4会产生长期缺血，伴有肿瘤核心坏死，但留下一圈存活组织。相比之下，单独递送CA4在实验性大鼠胶质瘤模型中没有治疗效果。
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