Brown Stephen L, Snyder James M, Ali Meser M
Department of Neurosurgery, USA.
Nov Approaches Cancer Study. 2021;6(3):609-614. doi: 10.31031/nacs.2021.06.000639. Epub 2021 Oct 20.
In brain tumors, delivering nanoparticles across the blood-brain tumor barrier presents a major challenge. Dual mode magnetic resonance imaging and fluorescent imaging probes have been developed where relaxation based Gd-DOTA or ParaCEST agents and a Near-Infrared (NIR) fluorescent dye, DL680 were conjugated on the surface of dendrimer. The and imaging of the dual-modality contrast agent showed excellent potential utility for identifying the location of glioma tumors. Systemic delivery of the subsequent nano-sized agent demonstrated glioma-specific accumulation, probably due to the enhanced permeability and retention effect. The biodistribution studies revealed the G5 agents have accumulated in the glioma tumor and the liver while a G3 agent only accumulated in the brain tumor but not in the liver or kidney. Hydrophobic drug molecules like Combrestatin A4 (CA4) or curcumin have also been conjugated with dendrimers that provided high aqueous solubility with improved therapeutic effect.
在脑肿瘤中，使纳米颗粒穿过血脑肿瘤屏障是一项重大挑战。已经开发出双模式磁共振成像和荧光成像探针，其中基于弛豫的钆-多胺多羧络合剂或顺磁化学交换饱和转移（ParaCEST）剂与近红外（NIR）荧光染料DL680共轭在树枝状聚合物表面。双模态造影剂的磁共振成像和荧光成像显示出在识别胶质瘤肿瘤位置方面具有出色的潜在效用。随后的纳米尺寸试剂的全身递送显示出胶质瘤特异性积累，这可能是由于增强的渗透和滞留效应。生物分布研究表明，G5试剂在胶质瘤肿瘤和肝脏中积累，而G3试剂仅在脑肿瘤中积累，而不在肝脏或肾脏中积累。疏水性药物分子如康普瑞汀A4（CA4）或姜黄素也已与树枝状聚合物共轭，从而提供了高水溶性并提高了治疗效果。
