Kiss Christopher R, Lau Jillian S Y, Yeung Alex, Woolley Ian
Monash Health, Clayton, VIC, Australia.
Department of Infectious Diseases, Alfred Hospital, Prahran, VIC, Australia.
Int J Clin Pharm. 2019 Feb;41(1):18-21. doi: 10.1007/s11096-018-00781-4. Epub 2019 Jan 17.
Background In Australia, it is not known how much antibiotic prescribing by infectious diseases physicians is long-term, or how confident they are with the evidence behind this practice. Objective Survey Australian infectious diseases physicians to assess attitudes and prescribing practice prescribing prolonged courses of antibiotics. Methods An online questionnaire was distributed to the mailing group for the Australian Society of Infectious Diseases. Responses were collected from 29th October to 12th November 2015. Results The majority of respondents practiced in Australia as Infectious Diseases physicians, microbiologists, or trainees. 88% had prescribed long-term antibiotics. Heterogeneity was noted in the indications for prescription, including recurrent UTIs, cellulitis or chest infections, prosthetic joint infection and vascular graft infection. Beta-lactams antibiotics were prescribed most frequently. 22% of respondents had prescribed rifampicin/fusidic acid most frequently, while 11% could not identify a single antibiotic that they used most frequently, due to the heterogeneity of indications for prescribing. 95% stated that they would stop long-term antibiotic therapy if appropriate, and 74% were willing to enrol their patients into a randomised control trial looking at stopping long-term therapy. Conclusion Most infectious diseases physicians who responded to the survey prescribe long-term antibiotics, with great heterogeneity in the indications for which these antibiotics are prescribed.
背景 在澳大利亚，尚不清楚传染病医生开具的抗生素长期处方量有多少，也不清楚他们对这种做法背后的证据有多大信心。目的 调查澳大利亚传染病医生，以评估他们对抗生素长期疗程处方的态度和处方做法。方法 向澳大利亚传染病学会的邮件群组发放在线问卷。于2015年10月29日至11月12日收集回复。结果 大多数受访者在澳大利亚作为传染病医生、微生物学家或实习生执业。88%的人曾开具过长期抗生素处方。在处方适应症方面存在异质性，包括复发性尿路感染、蜂窝织炎或胸部感染、人工关节感染和血管移植物感染。β-内酰胺类抗生素的处方最为频繁。22%的受访者最常开具利福平/夫西地酸，而11%的人由于处方适应症的异质性，无法确定他们最常使用的单一抗生素。95%的人表示，如果合适，他们会停止长期抗生素治疗，74%的人愿意让他们的患者参加一项关于停止长期治疗的随机对照试验。结论 参与调查的大多数传染病医生都开具长期抗生素处方，这些抗生素的处方适应症存在很大异质性。
