Tumor Microenvironment Research Branch, Division of Basic Science, Research Institute, National Cancer Center, Goyang, Gyonggi-do, Republic of Korea.
Arch Pharm Res. 2019 Feb;42(2):140-149. doi: 10.1007/s12272-019-01115-2. Epub 2019 Jan 17.
Long-term investigation and extensive efforts using sequencing and -omics analysis identified thousands of mutations in a single tumor. However, we cannot succeed at curing cancer by targeting mutations as the cause of cancer. Therefore, as an alternate therapeutic approach from classical oncology study, stimulation of the inherent ability of the immune system to attack tumor cells was welcome as a new principle in cancer therapy. However, it cannot be a permanent solution for the question of "which is the common factor that can distinguish cancer from normal?" Targeting the cancer energy metabolism may be a cancer-specific therapy for all kinds of cancer because normal cells do not rely on cancer energy metabolism under normal conditions. Here, trends of cancer metabolism as well as a new theory of cancer energy metabolism in the therapeutic approach is summarized.
长期的研究和广泛的努力，包括测序和组学分析，在单个肿瘤中发现了数千个突变。然而，我们不能通过针对导致癌症的突变来成功治愈癌症。因此，作为经典肿瘤学研究的一种替代治疗方法，刺激免疫系统攻击肿瘤细胞的固有能力作为癌症治疗的新原则受到欢迎。然而，它不能成为解决“是什么共同因素可以将癌症与正常区分开来？”的永久方案。针对癌症的能量代谢可能是针对各种癌症的一种癌症特异性治疗方法，因为正常细胞在正常情况下并不依赖于癌症的能量代谢。在这里，总结了癌症代谢的趋势以及治疗方法中癌症能量代谢的新理论。
