Bailey Ryan S, Sheldon Julie D, Allender Matthew C, Papich Mark G, Chinnadurai Sathya K
The Chicago Zoological Society, Brookfield, Illinois.
Illinois Zoological and Aquatic Animal Medicine Residency Program, Urbana, Illinois.
J Vet Pharmacol Ther. 2019 Jul;42(4):380-384. doi: 10.1111/jvp.12743. Epub 2019 Jan 17.
This study documents the pharmacokinetics of oral tramadol in Muscovy ducks. Six ducks received a single 30 mg/kg dose of tramadol, orally by stomach tube, with blood collection prior to and up to 24 hr after tramadol administration. Plasma tramadol, and metabolites O-desmethyltramadol (M1), and N,O-didesmethyltramadol (M5) concentrations were determined by high-pressure liquid chromatography (HPLC) with fluorescence (FL) detection. Pharmacokinetic parameters were calculated using a one-compartment model with first-order input. No adverse effects were noted after oral administration. All ducks achieved plasma concentrations of tramadol above 0.10 μg/ml and maintained those concentrations for at least 12 hr. Elimination half-life was 3.95 hr for tramadol in ducks, which is similar to other avian species. All ducks in this study produced the M1 metabolite and maintained plasma concentrations above 0.1 μg/ml for at least 24 hr.
本研究记录了番鸭口服曲马多的药代动力学。六只番鸭通过胃管口服单剂量30mg/kg的曲马多，并在给药前及给药后长达24小时进行采血。采用带荧光（FL）检测的高压液相色谱法（HPLC）测定血浆中曲马多及其代谢产物O-去甲基曲马多（M1）和N,O-二去甲基曲马多（M5）的浓度。使用具有一级输入的单室模型计算药代动力学参数。口服给药后未观察到不良反应。所有番鸭的曲马多血浆浓度均达到0.10μg/ml以上，并维持该浓度至少12小时。番鸭体内曲马多的消除半衰期为3.95小时，这与其他鸟类相似。本研究中的所有番鸭均产生M1代谢产物，且其血浆浓度维持在0.1μg/ml以上至少24小时。
