Tabaczar Sabina, Wołosiewicz Marcin, Filip Anna, Olichwier Adam, Dobrzyń Paweł
Pracownia Molekularnej Biochemii Medycznej, Instytut Biologii Doświadczalnej im. M. Nenckiego, PAN, ul. Pasteura 3, 02-093 Warszawa.
Pracownia Molekularnej Biochemii Medycznej, Instytut Biologii Doświadczalnej PAN, ul. Pasteura 3, 02-093 Warszawa.
Postepy Biochem. 2018 Oct 25;64(3):183-189. doi: 10.18388/pb.2018_130.
The uptake and utilization of energetic substrates in the myocardium are under strict control, any disturbances of which may lead to myocardial dysfunction, such as in the case of ischemia and heart failure. Stearoyl-CoA desaturase (SCD) is an enzyme that converts saturated fatty acids to monounsaturated fatty acids. It is an important player in the regulation of heart metabolism. Our previous studies showed that SCD1 affects substrate utilization by the heart, with a preference for glucose. Large cohort studies established a positive correlation between the plasma fatty acid desaturation index and cardiovascular disease mortality. Therefore, SCD1 might serve as a potential target for future therapies. We review recent findings on the role of SCD1 in the heart, with a focus on cardiac metabolism reprogramming and its involvement in heart dysfunction.
心肌中高能底物的摄取和利用受到严格控制，其中任何干扰都可能导致心肌功能障碍，例如在缺血和心力衰竭的情况下。硬脂酰辅酶A去饱和酶（SCD）是一种将饱和脂肪酸转化为单不饱和脂肪酸的酶。它是心脏代谢调节中的重要参与者。我们之前的研究表明，SCD1影响心脏对底物的利用，更倾向于利用葡萄糖。大型队列研究证实血浆脂肪酸去饱和指数与心血管疾病死亡率之间存在正相关。因此，SCD1可能成为未来治疗的潜在靶点。我们综述了SCD1在心脏中作用的最新研究结果，重点关注心脏代谢重编程及其与心脏功能障碍的关系。
