Cui Na, Zhang Hongwei, Chen Zhi, Yu Zhanbiao
1 Department of ICU, Affiliated Hospital of Hebei University, Baoding, Hebei, P. R. China.
These authors contributed equally to this work.
J Int Med Res. 2019 Apr;47(4):1573-1579. doi: 10.1177/0300060518822404. Epub 2019 Jan 18.
To investigate the prognostic significance of serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with sepsis and those with septic shock.
Fifty-nine patients were divided into sepsis and septic shock groups, as well as survivor and non-survivor groups, according to the severity of the disease and patient survival. Serum PCT and CRP measurements at the time of hospitalization in the intensive care unit were examined.
On the 2nd, 3rd, and 5th days, the CRP level was higher in the non-survivor group than in the survivor group, and the serum CRP level was higher in patients in the septic shock group than in patients in the sepsis group. Regarding changes in serum PCT level in each group, the levels of PCT were significantly different between non-survivor and survivor groups, whereas they did not differ between patients in the sepsis and septic shock groups. Serum PCT kinetics (ΔPCT) were similar between groups.
Serum PCT and CRP have good clinical diagnostic and prognostic value for patients with sepsis and septic shock. Kinetic studies of PCT and CRP can improve sensitivity and accuracy when evaluating the prognosis of patients with sepsis and those with septic shock.
探讨血清降钙素原（PCT）和C反应蛋白（CRP）在脓毒症及脓毒性休克患者中的预后意义。
根据疾病严重程度和患者生存情况，将59例患者分为脓毒症组和脓毒性休克组，以及生存组和非生存组。检测重症监护病房住院时的血清PCT和CRP水平。
在第2、3和5天，非生存组的CRP水平高于生存组，脓毒性休克组患者的血清CRP水平高于脓毒症组患者。关于每组血清PCT水平的变化，非生存组和生存组之间的PCT水平有显著差异，而脓毒症组和脓毒性休克组患者之间的PCT水平无差异。各组间血清PCT动力学（ΔPCT）相似。
血清PCT和CRP对脓毒症及脓毒性休克患者具有良好的临床诊断和预后价值。PCT和CRP的动力学研究在评估脓毒症及脓毒性休克患者的预后时可提高敏感性和准确性。
