de Villard R, Ceillier-Hoppenot B, Flachaire E, Dalery J, Rebaud B, Maillet J, Revol O, Mamelle J C, Quincy C
Hôpital Neurologique, Lyon, France.
Pediatrie. 1988;43(8):703-8.
The effects of fenfluramine were studied in a group of 44 children with the autistic syndrome and in 26 non autistic children with behavior abnormalities, mostly hyperkinetic children, as a control group. The mean daily dosage was 0.65 mg/kg/day. There were 75% positive results in the autistic children and 77% in the control group. The clinical improvement appears to be mainly related to the control of the hyperactive behavior in the autistic children. Platelet serotonin levels were studied in both groups, showing a clear cut decrease during fenfluramine therapy with no significant differences between the 2 groups and no correlation between the clinical effects and the magnitude of the decrease.
在一组44名患有自闭症谱系障碍的儿童以及26名患有行为异常（主要是多动症儿童）的非自闭症儿童（作为对照组）中研究了芬氟拉明的效果。平均每日剂量为0.65毫克/千克/天。自闭症儿童中有75%的结果呈阳性，对照组中有77%的结果呈阳性。临床改善似乎主要与自闭症儿童多动行为的控制有关。对两组儿童的血小板血清素水平进行了研究，结果显示在芬氟拉明治疗期间血清素水平明显下降，两组之间无显著差异，且临床效果与下降幅度之间无相关性。
