Rozman C, Montserrat E
Postgraduate School of Haematology Farreras Valentí, Hospital Clínico, Universidad de Barcelona, Spain.
Nouv Rev Fr Hematol (1978). 1988;30(5-6):369-71.
In chronic lymphocytic leukaemia (CLL), bone marrow biopsy (BM) sections show different infiltration patterns (nodular, interstitial, mixed diffuse) with a fairly homogeneous distribution when bilateral biopsies are examined. Sequential studies demonstrate that these patterns represent a dynamic process reflecting the degree of lymphocytic burden. Moreover, BM histopathology (diffuse vs non-diffuse) is a highly significant prognostic parameter. Although partly related to clinical stages, BM patterns have prognostic value on their own. A combined clinicopathologic staging system (integrating clinical stages and bone marrow histology) predicts the outcome of CLL patients more accurately than clinical stages alone.
在慢性淋巴细胞白血病（CLL）中，骨髓活检（BM）切片显示出不同的浸润模式（结节状、间质状、混合弥漫性），当检查双侧活检时，其分布相当均匀。连续研究表明，这些模式代表了一个反映淋巴细胞负荷程度的动态过程。此外，BM组织病理学（弥漫性与非弥漫性）是一个高度重要的预后参数。尽管部分与临床分期相关，但BM模式本身具有预后价值。一个联合的临床病理分期系统（整合临床分期和骨髓组织学）比单独的临床分期更准确地预测CLL患者的预后。
