Boussiotis V A, Pangalis G A
1st Department of Internal Medicine, University of Athens School of Medicine, Greece.
Nouv Rev Fr Hematol (1978). 1988;30(5-6):471-3.
In a previous study we obtained a 50% response rate with alpha 2b Interferon in the first stages of chronic lymphocytic leukaemia. We have performed a second study randomizing 34 stage A patients, who were receiving no other treatment (8 non-treated controls and 26 patients who had been treated with 3 modalities). We obtained 17 responses (67%) with one complete haematological response (4%), 9 incomplete (34%) and 7 minor (37%). No bone marrow changes were noted after this treatment but there was a decrease in the lymph nodes or the spleen seen on three occasions. In a new randomised study we have studied the effects of the small doses of Interferon associated with chemotherapy.
在之前的一项研究中，我们使用α2b干扰素治疗慢性淋巴细胞白血病的第一阶段，获得了50%的缓解率。我们进行了第二项研究，将34例A期患者随机分组，这些患者未接受其他治疗（8例未治疗的对照患者和26例接受过3种治疗方式的患者）。我们获得了17例缓解（67%），其中1例完全血液学缓解（4%），9例不完全缓解（34%），7例轻微缓解（37%）。该治疗后未观察到骨髓变化，但有3次出现淋巴结或脾脏缩小。在一项新的随机研究中，我们研究了小剂量干扰素联合化疗的效果。
