Wang J-Q, Wang D-W, Wang X-L, Wang D-C, Lin X-M, Sun L-B
Department of Urology, the First Hospital of Shanxi Medical University, Taiyuan, China.
Eur Rev Med Pharmacol Sci. 2019 Jan;23(1):70-74. doi: 10.26355/eurrev_201901_16749.
The research aimed to investigate the correlation between serum P450arom and sex hormones in males with late-onset hypogonadism (LOH).
A total of 97 LOH patients and 301 matched healthy males of same age underwent androgen deficiency in the aging males (ADAM) and aging males' symptoms (AMS) scales as well as basic questionnaire survey. Serum P450arom, sex hormones, fasting blood glucose and lipid profiles were tested. General information, P450arom and sex hormone levels were compared between the LOH group and the control group. Pearson correlation analysis was used to analyze the correlation between serum P450arom concentration and AMS score, blood glucose, lipid profiles, body mass index (BMI) and sex hormones.
Compared with the control group, the fasting blood glucose, body mass index (BMI), and Estrogen/Total Testosterone ratio (E2/TT) were significantly increased in LOH group (p<0.05), while TT, E2 and testosterone secreting index (TSI) were significantly decreased (p<0.05). No significant difference in P450arom concentration was observed between the two groups (p>0.05). The serum P450arom concentration was not related to TT, E2/TT, AMS score, and BMI.
These findings suggested that the serum P450arom concentration is unrelated to LOH symptom score and sex hormone levels and could not be used as an observation index and diagnostic basis for LOH.
本研究旨在探讨迟发性性腺功能减退（LOH）男性患者血清芳香化酶（P450arom）与性激素之间的相关性。
共纳入97例LOH患者和301例年龄匹配的健康男性，进行老年男性雄激素缺乏（ADAM）量表、老年男性症状（AMS）量表评估以及基本问卷调查。检测血清P450arom、性激素、空腹血糖和血脂水平。比较LOH组和对照组的一般资料、P450arom和性激素水平。采用Pearson相关分析血清P450arom浓度与AMS评分、血糖、血脂、体重指数（BMI）和性激素之间的相关性。
与对照组相比，LOH组空腹血糖、体重指数（BMI）和雌二醇/总睾酮比值（E2/TT）显著升高（p<0.05），而睾酮（TT）、雌二醇（E2）和睾酮分泌指数（TSI）显著降低（p<0.05）。两组间P450arom浓度差异无统计学意义（p>0.05）。血清P450arom浓度与TT、E2/TT、AMS评分和BMI均无相关性。
这些结果表明，血清P450arom浓度与LOH症状评分和性激素水平无关，不能作为LOH的观察指标和诊断依据。
