Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
J Leukoc Biol. 2019 May;105(5):905-913. doi: 10.1002/JLB.MR0618-225R. Epub 2019 Jan 18.
It is well established that B cells play an important role during infections beyond antibody production. B cells produce cytokines and are APCs for T cells. Recently, it has become clear that several pathogenic bacterial genera, such as Salmonella, Brucella, Mycobacterium, Listeria, Francisella, Moraxella, and Helicobacter, have evolved mechanisms such as micropinocytosis induction, inflammasome down-regulation, inhibitory molecule expression, apoptosis induction, and anti-inflammatory cytokine secretion to manipulate B cell functions influencing immune responses. In this review, we summarize our current understanding of B cells as targets of bacterial infection and the mechanisms by which B cells become a niche for bacterial survival and replication away from extracellular immune responses such as complement and antibodies.
已经证实，B 细胞在感染过程中除了产生抗体外还发挥着重要作用。B 细胞可产生细胞因子，并作为 APC 激活 T 细胞。最近，人们已经清楚地认识到一些致病细菌属，如沙门氏菌、布鲁氏菌、分枝杆菌、李斯特菌、弗朗西斯菌、莫拉菌和幽门螺杆菌，已经进化出了一些机制，如诱导微胞饮作用、下调炎症小体、表达抑制分子、诱导细胞凋亡和分泌抗炎细胞因子，从而操纵 B 细胞功能，影响免疫反应。在这篇综述中，我们总结了我们目前对 B 细胞作为细菌感染靶点的理解，以及 B 细胞如何成为细菌在远离补体和抗体等细胞外免疫反应的情况下生存和复制的小生境的机制。
