Makkar Vanshika, Kamboj Mala, Narwal Anjali
Department of Oral Pathology and Microbiology, Post Graduate Institute of Dental Sciences, Pt. BD Sharma University of Medical Sciences, Rohtak, Haryana, India.
J Exp Ther Oncol. 2019 Jan;13(1):65-70.
Statement of the Problem: Benign appearing dentigerous cyst (DC), also the most common developmental odontogenic cyst, shows various complications due to its pluripotent cell lining. The spectrum of diseases produced by conversion of its pluripotent cell varies from unicystic ameloblastoma, intraosseous epidermoid and central mucoepidermoid carcinoma. So, the need of the hour is to be acquainted with the etiopathogenesis of DC at molecular level and an attempt should be made to minimize its rate of tumor conversion.
To analyze the potential complications, their demographic profile, disease characteristics which can arise from the dentigerous cyst, and to be geared up for such situations in future.
Retrospective analysis was conducted and data was collected from the requisition forms during the time frame 2011- 2016 in the Department at Government Dental College, Haryana. Histopathologically diagnosed cases of dentigerous cyst were reviewed by three different observers and recorded, out of which DCs that showed potential complications were reviewed in detail.
Six cases of DC out of 26 showed transformation into central mucoepidermoid carcinoma, adenomatoid odontogenic tumor (two) and ameloblastoma (three) respectively.
The present research highlights the probable complications of DC encountered in our institute and conscientious vigilance should be exercised while histopathological examination of biopsied specimens. This study further unravels the enigma behind the emergence of neoplasms arising from DC.
问题陈述：看似良性的含牙囊肿（DC），也是最常见的发育性牙源性囊肿，由于其具有多能性的细胞衬里而表现出各种并发症。其多能细胞转化产生的疾病谱包括单囊性成釉细胞瘤、骨内表皮样癌和中央黏液表皮样癌。因此，当务之急是在分子水平上了解含牙囊肿的病因发病机制，并应努力降低其肿瘤转化率。
分析含牙囊肿可能出现的并发症、其人口统计学特征、疾病特点，并为未来应对此类情况做好准备。
进行回顾性分析，从2011年至2016年期间哈里亚纳邦政府牙科学院该科室的申请表格中收集数据。由三名不同的观察者对组织病理学诊断为含牙囊肿的病例进行复查并记录，其中对显示有潜在并发症的含牙囊肿进行详细复查。
26例含牙囊肿病例中，分别有6例转化为中央黏液表皮样癌、腺样牙源性肿瘤（2例）和成釉细胞瘤（3例）。
本研究突出了我们研究所遇到的含牙囊肿可能出现的并发症，在对活检标本进行组织病理学检查时应保持认真警惕。本研究进一步揭示了含牙囊肿引发肿瘤的谜团。
