作为透皮给药贴片的印模型绿豆淀粉/PVA 生物材料膜。
Sulindac imprinted mungbean starch/PVA biomaterial films as a transdermal drug delivery patch.
机构信息
Department of Chemical and Biomolecular Engineering, Chonnam National University, Yeosu 59626, Republic of Korea.
Department of Energy & Resources Engineering, Chonnam National University, Gwangju 61186, South Korea.
出版信息
Carbohydr Polym. 2019 Mar 15;208:261-268. doi: 10.1016/j.carbpol.2018.12.076. Epub 2018 Dec 24.
In this work, biodegradable biomaterial films for sulindac (SLD) recognition are synthesized from mungbean starch (MBS), PVA, and plasticizers by using UV irradiation process and casting methods. The optimal UV irradiation time for the preparation of SLD imprinted biomaterials films was about 30 min. Mechanical properties, recognition ability, and SLD release property for prepared films were investigated. From the results of recognition ability, we verified that these SLD imprinted biomaterial films have the binding site for SLD. The release properties of SLD was examined with the change of pH and temperature. The results indicate that the SLD release in pH 10.0 was higher than in pH 4.0. SLD release was also evaluated using an artificial skin. Results of the artificial skin test verified that SLD was released constantly for 20 days.
在这项工作中，采用紫外光辐照法和浇铸法，由绿豆淀粉（MBS）、PVA 和增塑剂合成了用于舒林酸（SLD）识别的可生物降解生物材料薄膜。制备 SLD 印迹生物材料薄膜的最佳紫外光辐照时间约为 30 min。研究了所制备薄膜的机械性能、识别能力和 SLD 释放性能。从识别能力的结果中，我们验证了这些 SLD 印迹生物材料薄膜具有 SLD 的结合位点。通过改变 pH 值和温度来研究 SLD 的释放特性。结果表明，在 pH 值为 10.0 时的 SLD 释放量高于在 pH 值为 4.0 时的释放量。还使用人工皮肤评估了 SLD 的释放情况。人工皮肤测试的结果验证了 SLD 在 20 天内持续释放。
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