制备及释放性能的熊果苷印迹的菊粉/聚乙烯醇生物材料。
Preparation and release properties of arbutin imprinted inulin/polyvinyl alcohol biomaterials.
机构信息
Department of Chemical and Biomolecular Engineering, Chonnam National University, Yeosu, Jeonnam 59626, South Korea.
Department of Energy & Resources Engineering, Chonnam National University, Gwangju 61186, Republic of Korea.
出版信息
Int J Biol Macromol. 2020 Oct 15;161:763-770. doi: 10.1016/j.ijbiomac.2020.06.105. Epub 2020 Jun 15.
The main objective of this work was to prepare inulin (INL)/polyvinyl alcohol (PVA) biomaterials imprinted with arbutin (AR) as the target drug. INL from Jerusalem artichoke flour was extracted with hot water extraction method. INL/PVA biomaterials were synthesized with a casting method and a UV curing. The optimal UV curing time and sodium benzoate content were about 10 min and 0.1 wt%, respectively. The biomaterials were characterized by SEM and FT-IR analysis. Mechanical properties of prepared AR imprinted biomaterials were also investigated. AR release was examined with changes of pH at 36.5 °C. The AR release ratio was also investigated using artificial skin. It was found that AR was released constantly for 40 min. Results of drug release mechanism indicated that AR release followed the Fickian diffusion behavior, whereas drug release using artificial skin followed the non-Fickian diffusion behavior. Tyrosinase inhibitory (%) for AR imprinted biomaterials with/without the addition of GL were 58.8% and 79.2%, respectively.
本工作的主要目的是制备以熊果苷（AR）为模板药物的菊粉（INL）/聚乙烯醇（PVA）生物材料。INL 从菊芋粉中采用热水提取法提取。采用浇铸法和紫外光固化法合成 INL/PVA 生物材料。最佳紫外光固化时间和苯甲酸钠含量分别约为 10 min 和 0.1 wt%。通过 SEM 和 FT-IR 分析对生物材料进行了表征。还研究了制备的 AR 印迹生物材料的机械性能。在 36.5°C 时通过 pH 值的变化来检查 AR 的释放。还使用人工皮肤研究了 AR 的释放比例。结果表明，AR 在 40 分钟内持续释放。药物释放机制的结果表明，AR 释放遵循菲克扩散行为，而使用人工皮肤的药物释放遵循非菲克扩散行为。添加/不添加 GL 的 AR 印迹生物材料的酪氨酸酶抑制率（%）分别为 58.8%和 79.2%。
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