Central Laboratory, Linyi Central Hospital, No. 17 Jiankang Road, Linyi 276400, China.
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, No. 163 Xianlin Road, Nanjing 210023, China.
Mini Rev Med Chem. 2019;19(10):826-832. doi: 10.2174/1389557519666190119111125.
Glycyrrhizic acid (GA), a triterpene isolated from the roots and rhizomes of licorice, named Glycyrrhiza glabra, is the principal bioactive ingredient of anti-viral, anti-inflammatory and hepatoprotective effects. GA has been used in the clinical treatment of hepatitis, bronchitis, gastric ulcer, AIDS (acquired immunodeficiency syndrome), certain cancers and skin diseases. It has a direct effect on anti-HBV (hepatitis B virus) via affecting the HBsAg (hepatitis B surface antigen) to extracellular secretion, improving liver dysfunction in patients with chronic hepatitis B, and ultimately improving the immune status of HBV. GA can significantly inhibit the proliferation of HIV, showing an immune activation. The clinical application of GA on the prevention and treatments of various diseases may derive from its numerous pharmacological properties. This review provides the summary of the antiviral effects of GA on research progress and mechanism in recent years.
甘草酸（GA）是从甘草（Glycyrrhiza glabra）的根和根茎中分离得到的一种三萜，是具有抗病毒、抗炎和保肝作用的主要生物活性成分。GA 已用于临床治疗肝炎、支气管炎、胃溃疡、艾滋病（获得性免疫缺陷综合征）、某些癌症和皮肤病。它通过影响 HBsAg（乙型肝炎表面抗原）向细胞外分泌，直接作用于抗 HBV（乙型肝炎病毒），改善慢性乙型肝炎患者的肝功能，最终改善 HBV 的免疫状态。GA 能显著抑制 HIV 的增殖，表现出免疫激活作用。GA 在预防和治疗各种疾病中的临床应用可能源于其众多的药理特性。本文综述了近年来 GA 对病毒的抑制作用及其作用机制的研究进展。
