Boehringer Ingelheim Pharma GmbH & Co. KG, CNS Diseases, Birkendorfer Straße 65, 88397, Biberach an der Riss, Germany.
Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.
Neurosci Biobehav Rev. 2019 Feb;97:96-111. doi: 10.1016/j.neubiorev.2018.07.018. Epub 2019 Jan 16.
Following the Research Domain Criteria (RDoC) concept, major brain circuits are conserved in evolution and malfunctioning of a brain circuit will lead to specific behavioral symptoms. Reverse translation of patient-based findings from Alzheimer's disease (AD), schizophrenia (SZ) and major depression (MD) patients to preclinical models accordingly can be a starting point for developing a deeper understanding of the functional circuit biology and contribute to the validation of new hypotheses for therapeutic intervention in patients. In the context of the EU funded PRISM project, a preclinical test battery of tasks has been selected and aligned with the clinical test battery. It allows for assessment of social functioning, sensory processing, attention and working memory and is designed for validation of biological substrates from human molecular landscaping of social withdrawal. This review will broadly summarize the available literature on tasks for studying social behavior in rodents and outline the development of a preclinical test battery for the PRISM project by reverse translation.
根据“研究领域标准（RDoC）”的概念，大脑的主要回路在进化中是保守的，而大脑回路的功能障碍将导致特定的行为症状。将基于患者的阿尔茨海默病（AD）、精神分裂症（SZ）和重度抑郁症（MD）患者的发现反译为临床前模型，这可以作为深入了解功能回路生物学的起点，并有助于验证针对患者的治疗干预的新假设。在欧盟资助的 PRISM 项目的背景下，已经选择了一组临床前测试任务，并与临床测试电池相匹配。它可以评估社会功能、感觉处理、注意力和工作记忆，旨在验证从人类社交回避的分子景观中获得的生物学基质。这篇综述将广泛总结目前关于啮齿动物社会行为研究任务的文献，并通过反向翻译概述 PRISM 项目的临床前测试电池的开发。
