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[韦格纳肉芽肿:分类与治疗]

[Wegener's granulomatosis: classification and therapy].

作者信息

De Remee R A

机构信息

Abteilung für Thoraxerkrankungen und Innere Medizin Mayo-Klinik, Rochester, Minnesota.

出版信息

Acta Med Austriaca. 1988;15(3):65-8.

PMID:3066099
Abstract

Wegener's granulomatosis in its classic form is manifested by necrotizing granulomas of the upper and lower respiratory tract, focal necrotizing vasculitis involving both arteries and veins which may be widely disseminated, and focal necrotizing glomerulitis. The disease may present with incomplete expression involving any combination of the major sites, including the upper respiratory tract (E), the lung (L), or the kidney (K). A newly emerging test for the disease called antineutrophil cytoplasmic antibody (ANCA) shows promise in studying the disease in its various expressions. Standard current treatment includes glucocorticoids and cyclophosphamide. Recently, favorable reports of improvement on trimethoprim/sulfamethoxazole combination have appeared, suggesting the possibility that the disease may be incited by a microbial infection.

摘要

典型的韦格纳肉芽肿表现为上、下呼吸道的坏死性肉芽肿、累及动脉和静脉的局灶性坏死性血管炎(可广泛播散)以及局灶性坏死性肾小球肾炎。该疾病可能以不完全表现形式出现,涉及主要部位的任何组合,包括上呼吸道(E)、肺(L)或肾脏(K)。一种名为抗中性粒细胞胞浆抗体(ANCA)的该疾病新检测方法在研究其各种表现形式方面显示出前景。目前的标准治疗包括糖皮质激素和环磷酰胺。最近,关于甲氧苄啶/磺胺甲恶唑联合用药改善病情的有利报告出现了,这表明该疾病可能由微生物感染引发。

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