Somova L, Kamenov V, Doncheva M, Kirilov G, Vassileva M
Institute of Endocrinology and Gerontology, Department of Clinical Biochemistry, Medical Academy, Sofia.
Acta Physiol Pharmacol Bulg. 1988;14(3):57-62.
An attempt was undertaken to assess the relationship between the imbalance of lipid peroxides, thromboxane A2/prostacyclin and increased platelet aggregability during early (2 months) and late (6 months) stage of streptozotocin diabetes in rat. Thromboxane A2 and prostacyclin (PGI2) were estimated by their stable metabolic products TXB2 and 6-keto-PGF1 alpha respectively. The results showed: 1. There is a significant imbalance in TXA2 (a potent promoter of platelet aggregation) and PGI2 (a potent vasodilator and inhibitor of platelet aggregation). The ratio TXA2/PGI2 was increased by 38% in the early and by 69% in the late stage of diabetes. 2. Serum lipid peroxides increased significantly during early (four times) and late (five times) stage of diabetes. 3. There is a very good correlation between increased lipid peroxides and increased TXA2/PGI2 ratio (r = 0.71) in diabetic rats. 4. A pronounced increase in thrombin-induced platelet aggregation is consistent with the increased levels of lipid peroxides (r = 0.65) and TXA2/PGI2 ratio (r = 0.60). 5. All described changes correlate with the duration of the disease.
研究旨在评估链脲佐菌素诱导的糖尿病大鼠早期（2个月）和晚期（6个月）脂质过氧化物失衡、血栓素A2/前列环素与血小板聚集性增加之间的关系。血栓素A2和前列环素（PGI2）分别通过其稳定代谢产物TXB2和6-酮-PGF1α进行评估。结果显示：1. 血栓素A2（一种强力血小板聚集促进剂）和前列环素（PGI2，一种强力血管扩张剂和血小板聚集抑制剂）存在显著失衡。糖尿病早期TXA2/PGI2比值升高38%，晚期升高69%。2. 糖尿病早期（四倍）和晚期（五倍）血清脂质过氧化物显著增加。3. 糖尿病大鼠脂质过氧化物增加与TXA2/PGI2比值增加之间存在良好相关性（r = 0.71）。4. 凝血酶诱导的血小板聚集显著增加与脂质过氧化物水平升高（r = 0.65）和TXA2/PGI2比值升高（r = 0.60）一致。5. 所有上述变化均与疾病持续时间相关。
